# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2149800 | Binding | Inhibition of DPP4 in human plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | Homo sapiens | 25 | ALA2146473 | single protein format | Scientific Literature | |
2. | ALA2149801 | Binding | Inhibition of DPP4 in rat plasma using GLY-Pro-MCA as substrate after 60 mins by fluorescence assay | Rattus norvegicus | 22 | ALA2146473 | cell-free format | Scientific Literature | |
3. | ALA2149802 | Functional | Ex vivo inhibition of DDP4 in Wistar rat plasma using GLY-Pro-MCA as substrate at 3 umol/kg, po after 0.5 hrs by fluorescence assay | Rattus norvegicus | 24 | ALA2146473 | organism-based format | Scientific Literature | |
4. | ALA2149803 | Functional | Ex vivo inhibition of DDP4 in Wistar rat plasma using GLY-Pro-MCA as substrate at 3 umol/kg, po after 9 hrs by fluorescence assay | Rattus norvegicus | 24 | ALA2146473 | organism-based format | Scientific Literature | |
5. | ALA2149804 | Binding | Inhibition of human DPP8 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | Homo sapiens | 5 | ALA2146473 | cell-based format | Scientific Literature | |
6. | ALA2149805 | Binding | Inhibition of human DPP9 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay | Homo sapiens | 5 | ALA2146473 | cell-based format | Scientific Literature | |
7. | ALA2149806 | Binding | Selectivity ratio of IC50 for human DPP8 to IC50 for human DPP4 | Homo sapiens | 5 | ALA2146473 | assay format | Scientific Literature | |
8. | ALA2149807 | Binding | Selectivity ratio of IC50 for human DPP9 to IC50 for human DPP4 | Homo sapiens | 5 | ALA2146473 | assay format | Scientific Literature | |
9. | ALA4232377 | ADME | Elimination half life in human | Homo sapiens | 12 | ALA4229387 | organism-based format | Scientific Literature | |
10. | ALA4303805 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging | Homo sapiens | 5,612 | ALA4303101 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
11. | ALA4303810 | Functional | Antiviral activity against SARS-CoV-2 (USA-WA1/2020 strain) measured by imaging in HRCE cells at MOI 0.4 after 96 hrs (reported as hit score from 0-1 for on-disease vs off-disease activity: scores >0.6 considered hits) | Homo sapiens | 1,629 | ALA4303122 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
12. | ALA4432067 | Binding | Inhibition of human recombinant DPP4 (39 to 766 residues) using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assay | Homo sapiens | 7 | ALA4431324 | single protein format | Scientific Literature | |
13. | ALA4432068 | Binding | Inhibition of DPP4 in human plasma using Ala-Pro-AFC as substrate incubated for 1 hr by fluorescence assay | Homo sapiens | 1 | ALA4431324 | cell-free format | Scientific Literature | |
14. | ALA4432069 | Binding | Binding affinity to human recombinant DPP4 (39 to 766 residues) by surface plasmon resonance analysis | Homo sapiens | 9 | ALA4431324 | single protein format | Scientific Literature | |
15. | ALA4432070 | Binding | Binding affinity to human recombinant DPP4 (39 to 766 residues) assessed as association rate constant by surface plasmon resonance analysis | Homo sapiens | 8 | ALA4431324 | single protein format | Scientific Literature | |
16. | ALA4432071 | Binding | Binding affinity to human recombinant DPP4 (39 to 766 residues) assessed as dissociation rate constant by surface plasmon resonance analysis | Homo sapiens | 8 | ALA4431324 | single protein format | Scientific Literature | |
17. | ALA4432072 | Binding | Binding affinity to human recombinant DPP4 (39 to 766 residues) assessed as residence time on target by surface plasmon resonance analysis | Homo sapiens | 7 | ALA4431324 | single protein format | Scientific Literature | |
18. | ALA4432075 | Binding | Binding affinity to human recombinant DPP4 (39 to 766 residues) at 5 uM by isothermal titration calorimetry | Homo sapiens | 9 | ALA4431324 | single protein format | Scientific Literature | |
19. | ALA4495582 | Functional | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
20. | ALA4513082 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 |