# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2154047 | B | Inhibition of human mPGES-1 | Homo sapiens | 3 | ALA2150852 | single protein format | Scientific Literature | |
2. | ALA2154048 | B | Inhibition of human mPGES-1 assessed as production of PGE2 by cell based assay | Homo sapiens | 3 | ALA2150852 | cell-based format | Scientific Literature | |
3. | ALA2154049 | B | Inhibition of mPGES-1 in human whole blood | Homo sapiens | 3 | ALA2150852 | single protein format | Scientific Literature | |
4. | ALA3761673 | B | Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis | Homo sapiens | 20 | ALA3758174 | cell-based format | Scientific Literature | |
5. | ALA3761674 | B | Inhibition of mPGES1 in rhIL-1beta-stimulated human A549 cells assessed as PGE2 level treated for 18 hrs after 30 mins pre-incubation with rhIL-1beta by EIA method | Homo sapiens | 19 | ALA3758174 | cell-based format | Scientific Literature | |
6. | ALA3761675 | B | Inhibition of mPGES1 in LPS-induced human whole blood assessed as suppression of PGE2 response after 20 to 24 hrs by LC-MS/MS analysis | Homo sapiens | 19 | ALA3758174 | tissue-based format | Scientific Literature | |
7. | ALA3761680 | B | Inhibition of mPGES1 in LPS-induced dog whole blood assessed as suppression of PGE2 response pre-incubated for 30 mins followed by LPS addition and measured after 5 hrs by LC-MS/MS analysis | Canis lupus familiaris | 2 | ALA3758174 | tissue-based format | Scientific Literature | |
8. | ALA3761687 | B | Inhibition of human ERG at 10 uM | Homo sapiens | 1 | ALA3758174 | single protein format | Scientific Literature | |
9. | ALA3761688 | B | Inhibition of human ERG at 100 uM | Homo sapiens | 1 | ALA3758174 | single protein format | Scientific Literature | |
10. | ALA3761692 | B | Inhibition of COX in human A549 cells assessed as reduction in PGE2 production at 10 uM | Homo sapiens | 11 | ALA3758174 | cell-based format | Scientific Literature | |
11. | ALA3761693 | B | Inhibition of COX in human whole blood assessed as decrease in TXB2 production up to 30 uM | Homo sapiens | 11 | ALA3758174 | tissue-based format | Scientific Literature | |
12. | ALA3761694 | B | Inhibition of COX1 (unknown origin) at 100 uM | Homo sapiens | 1 | ALA3758174 | single protein format | Scientific Literature | |
13. | ALA3761696 | A | Oral bioavailability in beagle dog at 0.5 mg/kg after 0.25 to 24 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA3758174 | organism-based format | Scientific Literature | |
14. | ALA3761697 | A | Plasma concentration in beagle dog at 2 mg/kg, po after | Canis lupus familiaris | 1 | ALA3758174 | organism-based format | Scientific Literature | |
15. | ALA3761698 | B | Inhibition of rat microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA3758174 | cell-based format | Scientific Literature | |
16. | ALA4220551 | A | Drug metabolism in rat hepatocytes assessed as 2-amino-5-((R)-1-(carboxymethylamino)-3-((2-(2-chloro-5-(pivalamidomethyl)benzamido)-1H-imidazol-5-yl)disulfanyl)-1-oxopropan-2-ylamino)-5-oxopentanoic acid formation at 2 uM after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4219066 | cell-based format | Scientific Literature | |
17. | ALA4220553 | A | Drug metabolism in rat hepatocytes assessed as 2-chloro-5-((3-hydroxy-2,2-dimethylpropanamido)methyl)-N-(1H-imidazol-2-yl)benzamide formation at 2 uM after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4219066 | cell-based format | Scientific Literature | |
18. | ALA4220554 | A | Drug metabolism in dog hepatocytes assessed as 2-chloro-5-((3-hydroxy-2,2-dimethylpropanamido)methyl)-N-(1H-imidazol-2-yl)benzamide formation at 2 uM after 4 hrs by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4219066 | cell-based format | Scientific Literature | |
19. | ALA4220555 | A | Drug metabolism in human hepatocytes assessed as 2-chloro-5-((3-hydroxy-2,2-dimethylpropanamido)methyl)-N-(1H-imidazol-2-yl)benzamide formation at 2 uM after 4 hrs by LC-MS/MS analysis | Homo sapiens | 1 | ALA4219066 | cell-based format | Scientific Literature | |
20. | ALA4220556 | A | Drug metabolism in rat hepatocytes assessed as 2-chloro-N-(4,5-dihydroxy-4,5-dihydro-1H-imidazol-2-yl)-5-(pivalamidomethyl)benzamide formation at 2 uM after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4219066 | cell-based format | Scientific Literature |