Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 bloodstream forms assessed as reduction in cell viability after 70 hrs by alamar blue assay
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as mean survival days at 25 mg/kg, po administered on day 3 post-infection for 4 consecutive days measured until 60 days post infection (Rvb = 8 days)
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as mean survival days at 50 mg/kg, po administered on day 3 post-infection for 4 consecutive days measured until 60 days post infection (Rvb = 8 days)
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as cured mouse at 25 mg/kg, po administered on day 3 post-infection for 4 consecutive days measured until 60 days post infection
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as cured mouse at 50 mg/kg, po administered on day 3 post-infection for 4 consecutive days measured until 60 days post infection
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as mean survival days at 50 mg/kg, po administered on day 21 post-infection for 5 days measured until 180 days post infection (Rvb = 55.8 days)
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as mean survival days at 100 mg/kg, po administered on day 21 post-infection for 5 days measured until 180 days post infection (Rvb = 55.8 days)
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as mean survival days at 50 mg/kg, po, bid administered on day 21 post-infection for 5 days measured until 180 days post infection (Rvb = 57.2 days)
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as mean survival days at 100 mg/kg, po, bid administered on day 21 post-infection for 5 days measured until 180 days post infection (Rvb = 57.2 days)
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as disease cure incidence at 50 mg/kg, po administered on day 21 post-infection for 5 days measured until 180 days post infection
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as disease cure incidence at 50 mg/kg, po, bid administered on day 21 post-infection for 5 days measured until 180 days post infection
Antiparasitic activity against Trypanosoma brucei brucei GVR35 infected in mouse assessed as disease cure incidence at 100 mg/kg, po, bid administered on day 21 post-infection for 5 days measured until 180 days post infection
Genotoxicity in human lymphocytes assessed as micronucleated binucleate cells level at 120 ug/mL incubated for 3 hrs measured post 21 hrs recovery in absence of rat liver S9 fraction (Rvb = 0.60%)
Mutagenicity in nitroreductase deficient Salmonella typhimurium TA100NR assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in presence of rat liver S9 fraction by Ames test
Mutagenicity in Salmonella typhimurium TA100 assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in presence of rat liver S9 fraction by Ames test
Mutagenicity in nitroreductase deficient Salmonella typhimurium TA100NR assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in absence of rat liver S9 fraction by Ames test
Mutagenicity in Salmonella typhimurium TA100 assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in absence of rat liver S9 fraction by Ames test
Mutagenicity in Salmonella typhimurium TA98 assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in absence of rat liver S9 fraction by Ames test
Mutagenicity in nitroreductase deficient Salmonella typhimurium TA98NR assessed as lowest compound concentration causing mutagenic effect incubated at 16 to 5000 ug/plate at 37 degC for 3 days in absence of rat liver S9 fraction by Ames test