| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2162521 | B | Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
| 2. | ALA2162522 | B | Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
| 3. | ALA2162523 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 31 | ALA2157910 | assay format | Scientific Literature | |
| 4. | ALA2162524 | B | Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
| 5. | ALA2162525 | B | Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
| 6. | ALA2162526 | B | Selectivity ratio of IC50 for rat SGLT2 to IC50 for rat SGLT1 | Rattus norvegicus | 5 | ALA2157910 | assay format | Scientific Literature | |
| 7. | ALA2162527 | A | Metabolic stability of the compound in rat intestinal microsomes assessed as compound remaining at 50 uM after 30 mins | Rattus norvegicus | 6 | ALA2157910 | microsome format | Scientific Literature | |
| 8. | ALA2162528 | A | Metabolic stability of the compound in rat intestinal microsomes assessed as compound remaining at 50 uM after 60 mins | Rattus norvegicus | 5 | ALA2157910 | microsome format | Scientific Literature | |
| 9. | ALA2162529 | P | Solubility of the compound in distilled water | 6 | ALA2157910 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA2162530 | F | Antihyperglycemic activity in po dosed Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as reduction of plasma glucose level after 1 hr by oral mixed carbohydrate tolerance test | Rattus norvegicus | 3 | ALA2157910 | organism-based format | Scientific Literature | |
| 11. | ALA2162685 | T | Toxicity in Wistar rat assessed as overnight urinary glucose excretion at 10 mg/kg, po | Rattus norvegicus | 7 | ALA2157910 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!