# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2162521 | B | Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
2. | ALA2162522 | B | Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
3. | ALA2162523 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 31 | ALA2157910 | assay format | Scientific Literature | |
4. | ALA2162524 | B | Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
5. | ALA2162525 | B | Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
6. | ALA2162526 | B | Selectivity ratio of IC50 for rat SGLT2 to IC50 for rat SGLT1 | Rattus norvegicus | 5 | ALA2157910 | assay format | Scientific Literature | |
7. | ALA2162527 | A | Metabolic stability of the compound in rat intestinal microsomes assessed as compound remaining at 50 uM after 30 mins | Rattus norvegicus | 6 | ALA2157910 | microsome format | Scientific Literature | |
8. | ALA2162528 | A | Metabolic stability of the compound in rat intestinal microsomes assessed as compound remaining at 50 uM after 60 mins | Rattus norvegicus | 5 | ALA2157910 | microsome format | Scientific Literature | |
9. | ALA2162529 | P | Solubility of the compound in distilled water | 6 | ALA2157910 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA2162530 | F | Antihyperglycemic activity in po dosed Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as reduction of plasma glucose level after 1 hr by oral mixed carbohydrate tolerance test | Rattus norvegicus | 3 | ALA2157910 | organism-based format | Scientific Literature | |
11. | ALA2162532 | T | Toxicity in Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as soft feces at 1 to 10 mg/kg, po | Rattus norvegicus | 2 | ALA2157910 | organism-based format | Scientific Literature | |
12. | ALA2162533 | T | Toxicity in Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as diarrhea at 1 to 10 mg/kg, po | Rattus norvegicus | 2 | ALA2157910 | organism-based format | Scientific Literature | |
13. | ALA2162534 | T | Toxicity in Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as soft feces at 0.3 to 3 mg/kg, po | Rattus norvegicus | 1 | ALA2157910 | organism-based format | Scientific Literature | |
14. | ALA2162535 | T | Toxicity in Wistar rat streptozotocin-nicotinamide-induced diabetic model assessed as diarrhea at 0.3 to 3 mg/kg, po | Rattus norvegicus | 1 | ALA2157910 | organism-based format | Scientific Literature | |
15. | ALA2162536 | A | Plasma concentration in Sprague-Dawley rat at 10 mg/kg | Rattus norvegicus | 1 | ALA2157910 | organism-based format | Scientific Literature | |
16. | ALA2162685 | T | Toxicity in Wistar rat assessed as overnight urinary glucose excretion at 10 mg/kg, po | Rattus norvegicus | 7 | ALA2157910 | organism-based format | Scientific Literature | |
17. | ALA2329023 | F | Antidiabetic activity in streptzotocin-induced-diabetic Wistar rat model assessed as AUC (0 to 1 hr) of plasma glucose level at 3 mg/kg, po by oral liquid meal tolerance test relative to control | Rattus norvegicus | 1 | ALA2321755 | organism-based format | Scientific Literature | |
18. | ALA2329648 | F | Antidiabetic activity in streptzotocin-induced-diabetic Wistar rat model assessed as AUC (0 to 1 hr) of plasma glucose level at 1 mg/kg, po by oral liquid meal tolerance test relative to control | Rattus norvegicus | 1 | ALA2321755 | organism-based format | Scientific Literature | |
19. | ALA2329650 | F | Antidiabetic activity in streptzotocin-induced-diabetic Wistar rat model assessed as AUC (0 to 1 hr) of plasma glucose level at 3 mg/kg, po by oral liquid meal tolerance test | Rattus norvegicus | 1 | ALA2321755 | organism-based format | Scientific Literature | |
20. | ALA2329651 | A | Metabolic stability in rat intestinal microsomes assessed as compound remaining at 50 uM after 60 mins | Rattus norvegicus | 3 | ALA2321755 | microsome format | Scientific Literature |