# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2163022 | B | Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
2. | ALA2163023 | B | Selectivity ratio of IC50 for PS2 gamma-secretase to IC50 for PS1 gamma-secretase | 9 | assay format | Scientific Literature | |||
3. | ALA2163024 | F | Antialzheimer activity in transgenic CRND8 mouse assessed as decrease of amyloid beta-40 level in cortex at 30 mg/kg, po after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
4. | ALA2163025 | F | Antialzheimer activity in B6C3F1 mouse assessed as reduction of amyloid beta-40 level in plasma at 10 mg/kg, po after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA2163026 | F | Antialzheimer activity in B6C3F1 mouse assessed as reduction of amyloid beta-40 level in cortex at 10 mg/kg, po after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA2160914 | B | Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 production | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
7. | ALA2160915 | B | Inhibition of PS1 gamma-secretase assessed as reduction of amyloid beta-40 production by membrane based assay | 9 | assay format | Scientific Literature | |||
8. | ALA2160916 | F | Antialzheimer activity in transgenic CRND8 mouse assessed as decrease of amyloid beta-40 level in plasma at 30 mg/kg, po after 3 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
9. | ALA2320837 | F | Inhibition of gamma secretase in B6C3F1 mouse assessed as lowering of plasma amyloid beta40 production at 10 mg/kg, po measured at 3 hrs | Mus musculus | 11 | organism-based format | Scientific Literature | ||
10. | ALA2320839 | B | Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
11. | ALA2320840 | B | Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cells transfected with human APPSOW and APPLON after 5 hrs by sandwich immunoassay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
12. | ALA2320841 | B | Inhibition of gamma secretase-mediated amyloid beta40 production in HEK293 cell membranes transfected with human APPSOW and APPLON mutant after 5 hrs by sandwich immunoassay | Homo sapiens | 21 | cell-based format | Scientific Literature | ||
13. | ALA2320842 | F | Inhibition of gamma secretase in B6C3F1 mouse assessed as lowering of cortex amyloid beta40 production at 10 mg/kg, po measured at 3 hrs | Mus musculus | 10 | organism-based format | Scientific Literature |