| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2161770 | B | Binding affinity to Trypanosoma brucei MetRS at 100 uM by thermal shift assay | Trypanosoma brucei | 30 | assay format | Scientific Literature | ||
| 2. | ALA2161885 | B | Inhibition of Trypanosoma brucei MetRS aminoacylation activity assessed as reduction in [3H]methionine incorporation into Escherichia coli tRNA pre-incubated for 15 mins before tRNA addition and measured after 120 mins by scintillation counting | Trypanosoma brucei | 8 | assay format | Scientific Literature | ||
| 3. | ALA2161886 | B | Inhibition of human mitochondrial MetRS aminoacylation activity assessed as reduction in [3H]methionine incorporation into Escherichia coli tRNA pre-incubated for 15 mins before tRNA addition and measured after 120 mins by scintillation counting | Homo sapiens | 8 | single protein format | Scientific Literature | ||
| 4. | ALA2161887 | B | Selectivity ratio of IC50 for human MetRS to IC50 for Trypanosoma brucei MetRS | 8 | assay format | Scientific Literature | |||
| 5. | ALA2161888 | F | Growth inhibition of Trypanosoma brucei brucei 427 blood stream forms after 48 hrs by alamar blue assay | Trypanosoma brucei brucei | 8 | organism-based format | Scientific Literature | ||
| 6. | ALA2161889 | A | Cytotoxicity against human CRL8155 cells incubated for 48 hrs by alamar blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA2161890 | A | Cytotoxicity against human HepG2 cells incubated for 48 hrs by alamar blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature |
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