# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2161770 | B | Binding affinity to Trypanosoma brucei MetRS at 100 uM by thermal shift assay | Trypanosoma brucei | 30 | assay format | Scientific Literature | ||
2. | ALA2161885 | B | Inhibition of Trypanosoma brucei MetRS aminoacylation activity assessed as reduction in [3H]methionine incorporation into Escherichia coli tRNA pre-incubated for 15 mins before tRNA addition and measured after 120 mins by scintillation counting | Trypanosoma brucei | 8 | assay format | Scientific Literature | ||
3. | ALA2161886 | B | Inhibition of human mitochondrial MetRS aminoacylation activity assessed as reduction in [3H]methionine incorporation into Escherichia coli tRNA pre-incubated for 15 mins before tRNA addition and measured after 120 mins by scintillation counting | Homo sapiens | 8 | single protein format | Scientific Literature | ||
4. | ALA2161887 | B | Selectivity ratio of IC50 for human MetRS to IC50 for Trypanosoma brucei MetRS | 8 | assay format | Scientific Literature | |||
5. | ALA2161888 | F | Growth inhibition of Trypanosoma brucei brucei 427 blood stream forms after 48 hrs by alamar blue assay | Trypanosoma brucei brucei | 8 | organism-based format | Scientific Literature | ||
6. | ALA2161889 | A | Cytotoxicity against human CRL8155 cells incubated for 48 hrs by alamar blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA2161890 | A | Cytotoxicity against human HepG2 cells incubated for 48 hrs by alamar blue assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
8. | ALA2161891 | A | Permeability across MDCK2-MDR1 cells expressing MDR1 at 3 uM in presence of 2 uM P-gp inhibitor Elacridal by mass spectroscopy | Canis lupus familiaris | 7 | cell-based format | Scientific Literature | ||
9. | ALA2161892 | A | Permeability across MDCK2-MDR1 cells expressing MDR1 at 3 uM in absence of 2 uM P-gp inhibitor Elacridal by mass spectroscopy | Canis lupus familiaris | 7 | cell-based format | Scientific Literature | ||
10. | ALA2161894 | A | Cmax in mouse at 50 mg/kg, po administered as single dose measured over 6 hrs by MS/MS method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
11. | ALA2162442 | A | Tmax in mouse at 50 mg/kg, po administered as single dose measured over 6 hrs by MS/MS method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
12. | ALA2162443 | A | Half life in mouse at 50 mg/kg, po administered as single dose measured over 6 hrs by MS/MS method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
13. | ALA2162444 | A | AUC in mouse at 50 mg/kg, po administered as single dose measured over 6 hrs by MS/MS method | Mus musculus | 3 | organism-based format | Scientific Literature | ||
14. | ALA2162449 | A | Binding affinity to MDR1 expressed in MDCK2 cells assessed as absorptive quotient at at 3 uM in absence of 2 uM by mass spectroscopy | 8 | cell-based format | Scientific Literature | |||
15. | ALA2162452 | T | Selectivity index, ratio of EC50 for human CRL8155 cells to EC50 for Trypanosoma brucei brucei 427 | 3 | assay format | Scientific Literature | |||
16. | ALA2162453 | T | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for Trypanosoma brucei brucei 427 | 3 | cell-based format | Scientific Literature |