# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2162521 | B | Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
2. | ALA2162522 | B | Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Homo sapiens | 31 | ALA2157910 | cell-based format | Scientific Literature | |
3. | ALA2162523 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 31 | ALA2157910 | assay format | Scientific Literature | |
4. | ALA2162524 | B | Inhibition of rat SGLT1 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
5. | ALA2162525 | B | Inhibition of rat SGLT2 expressed in COS7 cells assessed as reduction of [14C]-AMG uptake | Rattus norvegicus | 6 | ALA2157910 | cell-based format | Scientific Literature | |
6. | ALA2162527 | A | Metabolic stability of the compound in rat intestinal microsomes assessed as compound remaining at 50 uM after 30 mins | Rattus norvegicus | 6 | ALA2157910 | microsome format | Scientific Literature | |
7. | ALA2162529 | P | Solubility of the compound in distilled water | 6 | ALA2157910 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA2162685 | T | Toxicity in Wistar rat assessed as overnight urinary glucose excretion at 10 mg/kg, po | Rattus norvegicus | 7 | ALA2157910 | organism-based format | Scientific Literature | |
9. | ALA2329661 | B | Inhibition of human SGLT2 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake | Homo sapiens | 29 | ALA2321755 | cell-based format | Scientific Literature | |
10. | ALA2329662 | B | Selectivity ratio of IC50 for human SGLT2 to IC50 for human SGLT1 | Homo sapiens | 29 | ALA2321755 | assay format | Scientific Literature | |
11. | ALA2329663 | B | Inhibition of human SGLT1 expressed in COS7 cells assessed as inhibition [14C]-AMG cellular uptake | Homo sapiens | 29 | ALA2321755 | cell-based format | Scientific Literature |