# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2167991 | B | Inhibition of TACE using Mca-PLAQAV-Dpa-RSSSR-NH2 as substrate preincubated 15 mins measured every 30 sec for 30 mins | 7 | single protein format | Scientific Literature | |||
2. | ALA2167992 | B | Inhibition of human ADAMTS-5 expressed in CHO cells using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr by FRET assay | Homo sapiens | 54 | cell-based format | Scientific Literature | ||
3. | ALA2167993 | B | Inhibition of ADAMTS-4 using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr | 7 | single protein format | Scientific Literature | |||
4. | ALA2167994 | B | Inhibition of MMP-13 using 5-FAM-TPGPLGL[Dap- (DNP)]ARRK(5-TAMRA)-amide as substrate after 45 mins | 7 | single protein format | Scientific Literature | |||
5. | ALA2167995 | B | Inhibition of ADAMTS-1 using FAM (5-carbosyfluorescein)-AE*LQGRPISIAK substrate after 2 hrs | 7 | single protein format | Scientific Literature | |||
6. | ALA2167996 | P | Solubility of the compound in phosphate buffered saline at pH 7.4 after 1 hr | 3 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA2167997 | A | Permeability of the compound across artificial membrane by HPLC analysis | 3 | assay format | Scientific Literature | |||
8. | ALA2167998 | A | Apparent intrinsic clearance in rat liver microsomes at 0.5 uM by LCMS/MS analysis | Rattus norvegicus | 3 | microsome format | Scientific Literature | ||
9. | ALA2168191 | B | Selectivity ratio of IC50 for human ADAMTS-5 over IC50 for ADAMTS-1 | Homo sapiens | 6 | assay format | Scientific Literature | ||
10. | ALA2168192 | B | Selectivity ratio of IC50 for human ADAMTS-5 over IC50 for MMP-13 | Homo sapiens | 6 | assay format | Scientific Literature | ||
11. | ALA2168193 | B | Selectivity ratio of IC50 for human ADAMTS-5 over IC50 for TACE | Homo sapiens | 6 | assay format | Scientific Literature | ||
12. | ALA2168194 | B | Selectivity ratio of IC50 for human ADAMTS-5 over IC50 for ADAMTS-4 | Homo sapiens | 6 | assay format | Scientific Literature |