# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2167362 | F | Agonist activity at glucosylceramidase N444P mutant in lymphoblast obtained from Gaucher disease patient using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 1 uM for 3 days measured 2 hrs post substrate addition by fluorescence assay relative to untreated control | Homo sapiens | 1 | ALA2163314 | assay format | Scientific Literature | |
2. | ALA2168205 | F | Agonist activity at glucosylceramidase N370S mutant in lymphoblast obtained from Gaucher disease patient using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 10 uM for 3 days measured 2 hrs post substrate addition by fluorescence assay relative to untreated control | Homo sapiens | 1 | ALA2163314 | assay format | Scientific Literature | |
3. | ALA2168207 | B | Inhibition of lysosomal alpha-galactosidase in human fibroblast at 50 uM after 24 hrs | Homo sapiens | 6 | ALA2163314 | single protein format | Scientific Literature | |
4. | ALA2168208 | B | Inhibition of lysosomal beta-galactosidase in human fibroblast at 50 uM after 24 hrs | Homo sapiens | 6 | ALA2163314 | single protein format | Scientific Literature | |
5. | ALA2168209 | B | Inhibition of lysosomal alpha-glucosidase in human fibroblast at 50 uM after 24 hrs | Homo sapiens | 6 | ALA2163314 | single protein format | Scientific Literature | |
6. | ALA2168211 | B | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 5.2 by Lineweaver-Burk plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
7. | ALA2168212 | B | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 7.0 Lineweaver-Burk plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
8. | ALA2168213 | B | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 5.2 by Dixon plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
9. | ALA2168214 | B | Competitive inhibition of recombinant Imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition at pH 7.0 by Dixon plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
10. | ALA2168215 | B | Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition by Lineweaver-Burk plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
11. | ALA2168216 | B | Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate addition by Dixon plot assay | 10 | ALA2163314 | single protein format | Scientific Literature | ||
12. | ALA2168217 | B | Inhibition of lysosomal beta-glucosidase in human fibroblast using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated at 50 uM for 24 hrs before substrate addition measured after 2 hrs by fluorimetry | Homo sapiens | 4 | ALA2163314 | single protein format | Scientific Literature | |
13. | ALA2168425 | B | Inhibition of GBA2 activity in mouse tissue homogenate at 50 uM | Mus musculus | 10 | ALA2163314 | assay format | Scientific Literature | |
14. | ALA2168426 | B | Inhibition of bakers yeast alpha-glucosidase at100 uM | Saccharomyces cerevisiae | 9 | ALA2163314 | assay format | Scientific Literature | |
15. | ALA2168427 | B | Inhibition of rice alpha-glucosidase at 100 uM | Oryza sativa | 9 | ALA2163314 | assay format | Scientific Literature | |
16. | ALA2168428 | B | Inhibition of almond beta-glucosidase at 100 uM | Prunus dulcis | 9 | ALA2163314 | assay format | Scientific Literature | |
17. | ALA2168429 | B | Inhibition of green coffee beans alpha-galactosidase at 100 uM | Coffea arabica | 9 | ALA2163314 | single protein format | Scientific Literature | |
18. | ALA2168432 | B | Stabilization of recombinant imiglucerase at 50 uM at 48 degC after 60 mins by fluorimetry relative to incubation at 37 degC | 4 | ALA2163314 | assay format | Scientific Literature |