| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2166513 | F | Antagonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells inhibition of of histamine-induced GTP hydrolysis by steady state GTPase activity assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA2166516 | F | Agonist activity at human H2R-C17Y-A271D Gsalphas mutant containing human H2 receptor E2 loop expressed in Sf9 cells by steady state GTPase activity assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA2166518 | F | Intrinsic agonist activity at human H2R-Gsalphas expressed in Sf9 cells by steady state GTPase activity assay relative to histamine | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 4. | ALA2166519 | F | Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 5. | ALA2166520 | B | Potency index, ratio of pEC50 for compound to pEC50 for histamine at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | Homo sapiens | 18 | cell-based format | Scientific Literature | ||
| 6. | ALA2166521 | F | Intrinsic agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells by steady state GTPase activity assay relative to histamine | Cavia porcellus | 21 | cell-based format | Scientific Literature | ||
| 7. | ALA2166522 | F | Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | Cavia porcellus | 22 | cell-based format | Scientific Literature | ||
| 8. | ALA2166523 | B | Potency index, ratio of pEC50 for compound to pEC50 for histamine at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay | Cavia porcellus | 21 | cell-based format | Scientific Literature | ||
| 9. | ALA2166525 | B | Selectivity index, ratio of EC50 for human H2R-Gsalphas to EC50 for guinea pig H2R-Gsalphas by by steady state GTPase activity assay | 19 | assay format | Scientific Literature | |||
| 10. | ALA2166526 | F | Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rate | Cavia porcellus | 10 | tissue-based format | Scientific Literature | ||
| 11. | ALA2166527 | B | Potency index, ratio of pEC50 for compound to pEC50 for H2R in spontaneously beating guinea pig right atrium | Cavia porcellus | 9 | single protein format | Scientific Literature | ||
| 12. | ALA2166528 | F | Intrinsic agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rate relative to histamine | Cavia porcellus | 9 | tissue-based format | Scientific Literature | ||
| 13. | ALA2166530 | F | Antagonist activity at human H1R-RGS4 expressed in Sf9 cells by steady state GTPase activity assay | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 14. | ALA2166531 | F | Antagonist activity at human H3R-Galphai2-Gbeta1gamma2-RGS4 expressed in Sf9 cells assessed as inhibition of of histamine-induced GTP hydrolysis by steady state GTPase activity assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 15. | ALA2166535 | F | Agonist activity at guinea pig H2R hE2 loop Gsalphas mutant containing human H2 receptor E2 loop expressed in Sf9 cells by steady state GTPase activity assay | Cavia porcellus | 8 | cell-based format | Scientific Literature |
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