# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2173480 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
2. | ALA2173481 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
3. | ALA2173482 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.01 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
4. | ALA2173483 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
5. | ALA2173484 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
6. | ALA2173485 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
7. | ALA2173486 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.01 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
8. | ALA2173487 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
9. | ALA2173488 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
10. | ALA2173489 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
11. | ALA2173490 | F | Antagonist at human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
12. | ALA2173573 | F | Antagonist at human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
13. | ALA2173574 | F | Antagonist at human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
14. | ALA2173278 | B | Displacement of [3H]flumazenil from central benzodiazepine receptor in bovine cortical membrane after 90 mins by beta liquid scintillation counting | Bos taurus | 23 | ALA2169854 | cell membrane format | Scientific Literature | |
15. | ALA2173279 | B | Displacement of [3H]flumazenil from central benzodiazepine receptor in human cortical membrane after 90 mins by beta liquid scintillation counting | Homo sapiens | 15 | ALA2169854 | cell membrane format | Scientific Literature | |
16. | ALA2173280 | B | Ratio of Ki for central benzodiazepine receptor in bovine cortical membrane to Ki for central benzodiazepine receptor in bovine cortical membrane in presence of 50 uM GABA | Bos taurus | 15 | ALA2169854 | cell membrane format | Scientific Literature | |
17. | ALA2173281 | B | Ratio of Ki for central benzodiazepine receptor in human cortical membrane to Ki for central benzodiazepine receptor in human cortical membrane in presence of 50 uM GABA | Homo sapiens | 7 | ALA2169854 | cell membrane format | Scientific Literature | |
18. | ALA2173284 | F | Antagonist activity at central benzodiazepine receptor in Sprague-Dawley rat cerebrocortical synaptoneurosomes assessed as effect on GABA-induced [36]chloride ion flow after 10 seconds by beta liquid scintillation counting | Rattus norvegicus | 4 | ALA2169854 | assay format | Scientific Literature | |
19. | ALA2173294 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.01 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature | |
20. | ALA2173295 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | ALA2169854 | cell-based format | Scientific Literature |