| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2173480 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA2173481 | B | Modulation of human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA2173482 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.01 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA2173483 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA2173484 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 6. | ALA2173485 | B | Modulation of human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA2173486 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.01 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA2173487 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 0.1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA2173488 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 1 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA2173489 | B | Modulation of human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as effect on GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique relative to control | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA2173490 | F | Antagonist at human recombinant GABA-A alpha1beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA2173573 | F | Antagonist at human recombinant GABA-A alpha1beta1gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA2173574 | F | Antagonist at human recombinant GABA-A alpha5beta2gamma2L receptor expressed in Xenopus laevis oocytes assessed as blockade of diazepam-induced potentiation of GABA-induced chloride current at 10 uM incubated 60 seconds before addition of GABA measured after 30 seconds at holding potential -70 mV by two-microelectrode voltage clamp technique | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA2173575 | B | Displacement of [3H]flumazenil from human recombinant GABA-A alpha2beta2gamma2L receptor expressed in HEK293 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA2173576 | B | Displacement of [3H]flumazenil from human recombinant GABA-A alpha5beta3gamma2L receptor in HEK293 cells | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA2173278 | B | Displacement of [3H]flumazenil from central benzodiazepine receptor in bovine cortical membrane after 90 mins by beta liquid scintillation counting | Bos taurus | 23 | cell membrane format | Scientific Literature | ||
| 17. | ALA2173279 | B | Displacement of [3H]flumazenil from central benzodiazepine receptor in human cortical membrane after 90 mins by beta liquid scintillation counting | Homo sapiens | 15 | cell membrane format | Scientific Literature | ||
| 18. | ALA2173280 | B | Ratio of Ki for central benzodiazepine receptor in bovine cortical membrane to Ki for central benzodiazepine receptor in bovine cortical membrane in presence of 50 uM GABA | Bos taurus | 15 | cell membrane format | Scientific Literature | ||
| 19. | ALA2173281 | B | Ratio of Ki for central benzodiazepine receptor in human cortical membrane to Ki for central benzodiazepine receptor in human cortical membrane in presence of 50 uM GABA | Homo sapiens | 7 | cell membrane format | Scientific Literature | ||
| 20. | ALA2173283 | F | Agonist activity at central benzodiazepine receptor in Sprague-Dawley rat cerebrocortical synaptoneurosomes assessed as increase in GABA-induced [36]chloride ion flow after 10 seconds by beta liquid scintillation counting | Rattus norvegicus | 2 | assay format | Scientific Literature |
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