| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2174134 | B | Selectivity ratio of IC50 for to IC50 for PKR to IC50 for GST tagged PERK cytoplasmic domain | 5 | ALA2169840 | assay format | Scientific Literature | ||
| 2. | ALA2174135 | B | Selectivity ratio of IC50 for to IC50 for HRI to IC50 for GST tagged PERK cytoplasmic domain | 5 | ALA2169840 | assay format | Scientific Literature | ||
| 3. | ALA2172937 | B | Inhibition of LCK | 3 | ALA2169840 | single protein format | Scientific Literature | ||
| 4. | ALA2172949 | B | Inhibition of Aurora B | 3 | ALA2169840 | single protein format | Scientific Literature | ||
| 5. | ALA2172950 | B | Inhibition of HRI assessed as EIF2AK1 phosphorylation | 5 | ALA2169840 | single protein format | Scientific Literature | ||
| 6. | ALA2172951 | B | Inhibition of PKR assessed as EIF2AK2 phosphorylation | 5 | ALA2169840 | single protein format | Scientific Literature | ||
| 7. | ALA2172952 | B | Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells at 0.3 uM after 2 hrs by Western blotting | Homo sapiens | 2 | ALA2169840 | cell-based format | Scientific Literature | |
| 8. | ALA2172954 | B | Inhibition of thapsigargin-induced autophosphorylation of PERK in human A549 cells after 2 hrs by Western blotting | Homo sapiens | 8 | ALA2169840 | cell-based format | Scientific Literature | |
| 9. | ALA2172956 | B | Inhibition of GST tagged PERK cytoplasmic domain mediated EIF2alpha phosphorylation | 25 | ALA2169840 | single protein format | Scientific Literature | ||
| 10. | ALA3988182 | F | GSK PKIS2: Screen against O. lienalis microfilariae, single point, at 3.1uM to assess reduction in motility. Compounds were also tested for cytotoxicity against Rhesus Monkey LLCMK2 cells. A score was assigned as follows: Score 3 = Good activity, 100 % motility reduction; Score 2 = Marginal/moderate activity, 50-99% motility reduction; Score 1 = Inactive, <50% motility reduction; Score 0 = Cytotoxic. | Onchocerca lienalis | 486 | ALA3988181 | cell-based format | Published Kinase Inhibitor Set 2 | |
| 11. | ALA5252697 | B | Inhibition of NEK1 (unknown origin) at 1 uM relative to control | Homo sapiens | 61 | ALA5252509 | single protein format | Scientific Literature | |
| 12. | ALA5252698 | B | Inhibition of NEK2 (unknown origin) at 1 uM relative to control | Homo sapiens | 43 | ALA5252509 | single protein format | Scientific Literature | |
| 13. | ALA5252699 | B | Inhibition of NEK3 (unknown origin) at 1 uM relative to control | Homo sapiens | 40 | ALA5252509 | single protein format | Scientific Literature | |
| 14. | ALA5252700 | B | Inhibition of NEK4 (unknown origin) at 1 uM relative to control | Homo sapiens | 46 | ALA5252509 | single protein format | Scientific Literature | |
| 15. | ALA5252701 | B | Inhibition of NEK5 (unknown origin) at 1 uM relative to control | Homo sapiens | 40 | ALA5252509 | single protein format | Scientific Literature | |
| 16. | ALA5252702 | B | Inhibition of NEK6 (unknown origin) at 1 uM relative to control | Homo sapiens | 42 | ALA5252509 | single protein format | Scientific Literature | |
| 17. | ALA5252703 | B | Inhibition of NEK7 (unknown origin) at 1 uM relative to control | Homo sapiens | 42 | ALA5252509 | single protein format | Scientific Literature | |
| 18. | ALA5252704 | B | Inhibition of NEK9 (unknown origin) at 1 uM relative to control | Homo sapiens | 42 | ALA5252509 | single protein format | Scientific Literature | |
| 19. | ALA5252705 | B | Inhibition of NEK10 (unknown origin) at 1 uM relative to control | Homo sapiens | 43 | ALA5252509 | single protein format | Scientific Literature | |
| 20. | ALA5252706 | B | Inhibition of NEK11 (unknown origin) at 1 uM relative to control | Homo sapiens | 40 | ALA5252509 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!