# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2176210 | ADME | Stability of the compound in mouse EMT6 cells assessed as parent compound level under hypoxic condition at 200 uM after 1 hr by HPLC analysis | Mus musculus | 1 | ALA2169860 | cell-based format | Scientific Literature | |
2. | ALA2176211 | ADME | Stability of the compound in mouse EMT6 cells assessed as parent compound level under oxic condition at 200 uM after 1 hr by HPLC analysis | Mus musculus | 1 | ALA2169860 | cell-based format | Scientific Literature | |
3. | ALA2176216 | Physicochemical | Aqueous solubility of the compound in distilled water relative to O6-BG | 5 | ALA2169860 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA2176217 | Physicochemical | Aqueous solubility of the compound in distilled water | 6 | ALA2169860 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA2176218 | Functional | Potentiation of laromustine-induced cytotoxicity against mouse EMT6 cells expressing human AGT assessed as cell survival fraction at 2 uM treated 2 hrs before laromustine addition measured after 18 hrs by clonogenic assay | Mus musculus | 4 | ALA2169860 | cell-based format | Scientific Literature | |
6. | ALA2176219 | ADME | Cytotoxicity against mouse EMT6 cells expressing human AGT assessed as cell survival fraction at 2 uM after 18 hrs by clonogenic assay | Mus musculus | 4 | ALA2169860 | cell-based format | Scientific Literature | |
7. | ALA2176220 | Binding | Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrs relative to O6-BG | Homo sapiens | 3 | ALA2169860 | cell-based format | Scientific Literature | |
8. | ALA2176221 | Binding | Inhibition of AGT in human HL60 cells assessed as AGT levels using [3H]AGT after 2 hrs | Homo sapiens | 4 | ALA2169860 | cell-based format | Scientific Literature | |
9. | ALA2176222 | Binding | Inhibition of purified recombinant human AGT assessed as ability to repair L1210 DNA containing cross-link precursor lesions at 0.01 to 1 uM after 10 mins | Homo sapiens | 4 | ALA2169860 | single protein format | Scientific Literature |