| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2174785 | F | Induction of morphological changes in wild type blood form of Trypanosoma brucei brucei assessed as multiple nuclei and kinetoplasts formation after 12 hrs by microscopic analysis | Trypanosoma brucei brucei | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 2. | ALA2174786 | F | Antitrypanosomal activity against wild type blood form of Trypanosoma brucei brucei assessed as parasite lysis at 10 uM after 48 hrs | Trypanosoma brucei brucei | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 3. | ALA2174787 | F | Induction of morphological changes in wild type blood form of Trypanosoma brucei brucei assessed as multiple nuclei and kinetoplasts formation at 10 uM after 12 hrs by microscopic analysis | Trypanosoma brucei brucei | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 4. | ALA2174788 | F | Increase in intracellular cAMP level in Trypanosoma brucei 427 expressing cAMP-FRET sensor by FRET assay | Trypanosoma brucei | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 5. | ALA2174789 | A | Therapeutic index, ratio of IC50 for Trypanosoma brucei rhodesiense STIB-900 to cytotoxicity against mouse macrophages | 1 | ALA2169737 | assay format | Scientific Literature | ||
| 6. | ALA2174790 | A | Cytotoxicity against mouse macrophages | Mus musculus | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 7. | ALA2174791 | A | Therapeutic index, ratio of IC50 for Trypanosoma brucei rhodesiense STIB-900 to IC50 for human MRC5 cells | 1 | ALA2169737 | cell-based format | Scientific Literature | ||
| 8. | ALA2174792 | F | Antitrypanosomal activity against trypomastigotes of Trypanosoma brucei rhodesiense STIB-900 after 72 hrs by fluorescence assay | Trypanosoma brucei rhodesiense | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 9. | ALA2174793 | F | Antitrypanosomal activity against trypomastigotes of Trypanosoma cruzi after 72 hrs by fluorescence assay | Trypanosoma cruzi | 1 | ALA2169737 | organism-based format | Scientific Literature | |
| 10. | ALA2174794 | B | Inhibition of human PDE4A1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Homo sapiens | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 11. | ALA2174795 | B | Inhibition of human PDE4D3 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Homo sapiens | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 12. | ALA2175357 | B | Inhibition of human PDE4C1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Homo sapiens | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 13. | ALA2175358 | B | Inhibition of human PDE4B1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Homo sapiens | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 14. | ALA2175361 | F | Antitrypanosomal activity against trypomastigotes of Trypanosoma brucei brucei Squib-427 after 72 hrs by fluorescence assay | Trypanosoma brucei brucei | 31 | ALA2169737 | organism-based format | Scientific Literature | |
| 15. | ALA2175362 | A | Cytotoxicity against human MRC5 cells after 72 hrs by resazurin assay | Homo sapiens | 31 | ALA2169737 | cell-based format | Scientific Literature | |
| 16. | ALA2175363 | B | Inhibition of Trypanosoma brucei recombinant TbrPDEB2 expressed in yeast assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Trypanosoma brucei | 1 | ALA2169737 | assay format | Scientific Literature | |
| 17. | ALA2175364 | B | Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP after 20 mins by PDELight assay | Trypanosoma brucei | 1 | ALA2169737 | assay format | Scientific Literature | |
| 18. | ALA2175365 | B | Inhibition of Leishmania major recombinant PDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Leishmania major | 1 | ALA2169737 | cell-based format | Scientific Literature | |
| 19. | ALA2175366 | B | Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proximity assay | Trypanosoma brucei | 31 | ALA2169737 | cell-based format | Scientific Literature | |
| 20. | ALA3832786 | F | AntiTrypanosoma brucei activity T. b. brucei IC50 (uM) | Trypanosoma brucei | 64 | ALA3832761 | organism-based format | MMV Pathogen Box |
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