Transrepressional activity at LXR in human TPA-activated THP1 cells assessed as inhibition of LPS-induced IL6 production incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA relative to 2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-5-methyl-11-methylene-5H-dibenzo[b,e]azepin-6(11H)-one
Transrepressional activity at LXR in human TPA-activated THP1 cells assessed as inhibition of LPS-induced IL6 production incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA
Inhibition of LPS-induced IL-1beta mRNA expression in LXRalpha-deficient C57BL/6J mouse peritoneal macrophages at 10 uM incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by RT-PCR analysis
Inhibition of LPS-induced IL-6 mRNA expression in LXRalpha-deficient C57BL/6J mouse peritoneal macrophages at 10 uM incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by RT-PCR analysis
Induction of LPS-induced IL-6 production in LXRalpha,LXRbeta-deficient C57BL/6J mouse peritoneal macrophages at 10 uM incubated for 6 hrs prior to LPS-induction measured after 18 hrs by ELISA
Inhibition of LPS-induced IL-6 production in LXRalpha,LXRbeta-deficient C57BL/6J mouse peritoneal macrophages at 10 uM incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA
Transrepressional activity at LXR in C57BL/6J mouse peritoneal macrophages assessed as inhibition of LPS-induced IL-1beta mRNA expression at 10 uM incubated for 6 hr prior to LPS-challenge measured after 18 hrs by RT-PCR analysis
Transrepressional activity at LXR in C57BL/6J mouse peritoneal macrophages assessed as inhibition of LPS-induced IL-6 mRNA expression at 10 uM incubated for 6 hr prior to LPS-challenge measured after 18 hrs by RT-PCR analysis
Transactivational antagonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luciferase activity at 30 uM after 16 hrs by reporter gene assay
Transactivational antagonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as inhibition of T1317-induced luciferase activity at 30 uM after 16 hrs by reporter gene assay
Transactivational agonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by reporter gene assay relative to N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzamide
Transactivational agonist activity at human LXRbeta transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by reporter gene assay
Transactivational agonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by reporter gene assay relative to N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylbenzamide
Transrepressional activity at LXR in human TPA-activated THP1 cells assessed as inhibition of LPS-induced IL6 production at 10 uM incubated for 6 hrs prior to LPS-challenge measured after 18 hrs by ELISA
Transactivational agonist activity at human LXRalpha transfected in HEK293 cells expressing CMX-Gal4N assessed as luciferase activity after 16 hrs by reporter gene assay