| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2174946 | A | Drug metabolism in Sprague-Dawley rat assessed as N-[6-(3-Hydroxypropyl)-5,11-dioxo-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-3-yl]acetamide level in mammary gland at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2175054 | A | Drug metabolism in Sprague-Dawley rat assessed as N-[6-(3-Hydroxypropyl)-5,11-dioxo-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-3-yl]acetamide level in serum at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2175055 | A | Drug metabolism in Sprague-Dawley rat assessed as N-[6-(3-Hydroxypropyl)-5,11-dioxo-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-3-yl]acetamide level in liver at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2175056 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-11-hydroxy-6-(3-hydroxypropyl)-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in mammary gland at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2175057 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-11-hydroxy-6-(3-hydroxypropyl)-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in serum at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2175058 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-11-hydroxy-6-(3-hydroxypropyl)-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in liver at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2175059 | A | Drug metabolism in Sprague-Dawley rat assessed as 6-(3-Hydroxypropyl)-3-amino-5H-indeno[1,2- c]-isoquinoline-5,11(6H)dione level in mammary gland at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2175060 | A | Drug metabolism in Sprague-Dawley rat assessed as 6-(3-Hydroxypropyl)-3-amino-5H-indeno[1,2- c]-isoquinoline-5,11(6H)dione level in serum at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA2175061 | A | Drug metabolism in Sprague-Dawley rat assessed as 6-(3-Hydroxypropyl)-3-amino-5H-indeno[1,2- c]-isoquinoline-5,11(6H)dione level in liver at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA2175062 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-6-(3-aminopropyl)-11-hydroxy-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in mammary gland at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA2175063 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-6-(3-aminopropyl)-11-hydroxy-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in serum at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA2175064 | A | Drug metabolism in Sprague-Dawley rat assessed as 3-Amino-6-(3-aminopropyl)-11-hydroxy-6,11-dihydro-5Hindeno[1,2-c]isoquinolin-5-one level in liver at 40 mg/kg, po administered 3 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA2175066 | A | Cytotoxicity against human HEK293 cells assessed as cell survival at 50 uM relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 14. | ALA2175528 | B | Inhibition of TNFalpha-induced human NFkappaB activity in HEK293 cells incubated for 6 hrs followed by compound wash out measured after 5 mins by by luciferase assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
| 15. | ALA2175529 | B | Inhibition of TNFalpha-induced human NFkappaB activity in HEK293 cells at 50 uM incubated for 6 hrs followed by compound wash out measured after 5 mins by by luciferase assay | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 16. | ALA2175530 | F | Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity at 1.25 to 20 uM after 25 hrs by luciferase reporter gene assay relative to bexarotene | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA2175531 | F | Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity at 1.25 to 20 uM after 4 to 6 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA2175532 | F | Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity at 5 uM after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA2175533 | F | Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity after 12 hrs by luciferase reporter gene assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 20. | ALA2175534 | F | Agonist activity at human RXRalpha expressed in african green monkey COS1 cells assessed as induction of RXRE transcriptional activity at 1.25 to 20 uM after 25 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |
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