# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2175668 | B | Inhibition of human ALK assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
2. | ALA2175669 | B | Inhibition of human MER assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
3. | ALA2175670 | B | Inhibition of human MAP4K2 assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
4. | ALA2175671 | B | Inhibition of human LTK assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
5. | ALA2175672 | B | Inhibition of human IRAK1 assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA2175673 | B | Inhibition of human LCK assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA2175674 | B | Inhibition of human INSR assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
8. | ALA2175675 | B | Inhibition of human FLT3 assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
9. | ALA2175676 | B | Inhibition of human AXL assessed as residual enzyme activity at 1 uM by Ambit kinome assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
10. | ALA2175677 | F | Time above in-vitro ALK IC50 in SCID-beige mouse xenografted with human KARPAS299 cells assessed as induction of body weight changes at 30 mg/kg, po qd for 15 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
11. | ALA2175678 | B | Binding affinity to human ALK by Ambit titration assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA2175787 | F | Antitumor activity against NPM-ALK driven human KARPAS299 cells xenografted in SCID-beige mouse assessed as inhibition of tumor growth administered orally once daily for 15 days | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA2175788 | A | Half life in iv dosed mouse | Mus musculus | 1 | organism-based format | Scientific Literature | ||
14. | ALA2175789 | T | Toxicity in SCID-beige mouse xenografted with human KARPAS299 cells assessed as induction of body weight changes at 60 mg/kg, po qd for 15 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
15. | ALA2175790 | T | Toxicity in SCID-beige mouse xenografted with human KARPAS299 cells assessed as induction of body weight changes at 30 mg/kg, po qd for 15 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
16. | ALA2175791 | F | Antitumor activity against NPM-ALK driven human KARPAS299 cells xenografted in SCID-beige mouse assessed as inhibition of tumor growth at 60 mg/kg, po qd for 15 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
17. | ALA2175792 | F | Antitumor activity against NPM-ALK driven human KARPAS299 cells xenografted in SCID-beige mouse assessed as inhibition of tumor growth at 30 mg/kg, po qd for 15 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
18. | ALA2175793 | F | Antitumor activity against NPM-ALK driven human KARPAS299 cells xenografted in SCID-beige mouse assessed as inhibition of tumor growth at 10 mg/kg, po qd for 15 days | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
19. | ALA2175794 | B | Inhibition of ALK R1275Q mutant | Homo sapiens | 2 | assay format | Scientific Literature | ||
20. | ALA2175795 | B | Inhibition of ALK L1196M mutant | Homo sapiens | 2 | assay format | Scientific Literature |