# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2173381 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as increase in SHP1 level at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA2169881 | cell-based format | Scientific Literature | |
2. | ALA2173382 | Functional | Agonist activity at SHP1 in human PLC5 cells at 10 uM after 6 hrs by immunoprecipitation method | Homo sapiens | 3 | ALA2169881 | cell-based format | Scientific Literature | |
3. | ALA2173469 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as decrease in pSTAT3-mediated cyclinD1 level at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA2169881 | cell-based format | Scientific Literature | |
4. | ALA2173470 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as decrease in pSTAT3-mediated survivin level at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA2169881 | cell-based format | Scientific Literature | |
5. | ALA2173471 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as decrease in pSTAT3-mediated Mcl1 level at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA2169881 | cell-based format | Scientific Literature | |
6. | ALA2173472 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as inhibition of STAT3 Y705 phosphorylation at 10 uM after 12 hrs by Western blot analysis | Homo sapiens | 4 | ALA2169881 | cell-based format | Scientific Literature | |
7. | ALA2173473 | Functional | Agonist activity at SHP1 in human PLC5 cells assessed as inhibition of IL6-induced STAT3 phosphorylation at 10 uM incubated for 24 hrs prior to IL6-induction measured after 30 mins by sandwich ELISA | Homo sapiens | 3 | ALA2169881 | cell-based format | Scientific Literature | |
8. | ALA2173474 | Functional | Cytotoxicity against human PLC5 cells by MTT assay | Homo sapiens | 17 | ALA2169881 | cell-based format | Scientific Literature |