# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2175604 | F | Antiinflammatory activity in A/J mouse assessed as inhibition of LPS-induced airway elastance provoked by methacholine at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
2. | ALA2175723 | F | Antiinflammatory activity in A/J mouse assessed as inhibition of LPS-induced airway resistance provoked by methacholine at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
3. | ALA2175728 | F | Antiinflammatory activity in A/J mouse assessed as inhibition of neutrophil accumulation in bronchoalveolar space at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
4. | ALA2175730 | F | Antiinflammatory activity in A/J mouse assessed as inhibition of leukocyte accumulation in bronchoalveolar space at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
5. | ALA2175732 | F | Antiinflammatory activity in A/J mouse lung assessed as inhibition of LPS-induced IL6 production at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
6. | ALA2175734 | F | Antiinflammatory activity in A/J mouse lung assessed as inhibition of LPS-induced TNFalpha production at 100 umol/kg, po administered 1 hr prior to LPS-challenge measured after 18 hrs relative to vehicle-treated control | Mus musculus | 9 | organism-based format | Scientific Literature | ||
7. | ALA2175736 | F | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 24 hrs by ELISA | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
8. | ALA2175737 | B | Selectivity ratio of IC50 for bovine PDE5 to IC50 for bovine PDE4 | Bos taurus | 1 | assay format | Scientific Literature | ||
9. | ALA2175738 | F | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production at 10 uM after 24 hrs by ELISA relative to control | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
10. | ALA2175742 | B | Inhibition of PDE6 at 10 uM | 6 | assay format | Scientific Literature | |||
11. | ALA2175743 | B | Inhibition of bovine PDE5 using [3H]cAMP as substrate | Bos taurus | 1 | assay format | Scientific Literature | ||
12. | ALA2175745 | B | Inhibition of bovine PDE3 using [3H]cAMP as substrate | Bos taurus | 7 | assay format | Scientific Literature | ||
13. | ALA2175747 | B | Inhibition of human PDE2 using [3H]cAMP as substrate at 10 uM | Homo sapiens | 7 | single protein format | Scientific Literature | ||
14. | ALA2175749 | B | Inhibition of bovine PDE1 using [3H]cAMP as substrate at 10 uM | Bos taurus | 8 | assay format | Scientific Literature | ||
15. | ALA2175751 | B | Inhibition of human recombinant PDE4D | Homo sapiens | 6 | single protein format | Scientific Literature | ||
16. | ALA2175752 | A | Proemetic activity in A/J mouse assessed as reversal of xylazine/katamine-induced anesthesia at 30 to 200 umol/kg, sc administered 30 mins prior xylazine/ketamine-administration | Mus musculus | 2 | organism-based format | Scientific Literature | ||
17. | ALA2175753 | B | Inhibition of human recombinant PDE4C | Homo sapiens | 4 | single protein format | Scientific Literature | ||
18. | ALA2175754 | B | Inhibition of human recombinant PDE4B | Homo sapiens | 4 | single protein format | Scientific Literature | ||
19. | ALA2175862 | B | Inhibition of human recombinant PDE4A | Homo sapiens | 4 | single protein format | Scientific Literature | ||
20. | ALA2175863 | B | Inhibition of bovine PDE4 using [3H]cAMP as substrate | Bos taurus | 33 | assay format | Scientific Literature |