| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2187113 | A | Free drug concentration in C57BL/6 mouse brain at 125 umol/kg, po at 1.5 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA2187119 | A | Free drug concentration in C57BL/6 mouse plasma at 125 umol/kg, po at 1.5 hrs | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2187534 | F | Antialzheimer activity in C57BL/6 mouse assessed as reduction in sAPPbeta level in brain at 125 umol/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2187540 | F | Antialzheimer activity in C57BL/6 mouse assessed as reduction in amyloid beta 42 level in brain at 125 umol/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2187548 | A | Fraction unbound in C57BL/6 mouse brain at 125 umol/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2187555 | A | Fraction unbound in C57BL/6 mouse plasma at 125 umol/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2187560 | F | Antialzheimer activity in C57BL/6 mouse assessed as reduction in amyloid beta 40 level in brain at 125 umol/kg, po at 1.5 hrs by ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2187563 | B | Inhibition of BACE1-mediated amyloid beta 40 release in C57/BL6 mouse primary cortical neurons after overnight incubation by ELISA | Mus musculus | 9 | single protein format | Scientific Literature | ||
| 9. | ALA2182698 | B | Inhibition of human recombinant BACE2 using (europium)CEVNLDAEFK(Qsy7) as substrate incubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRET assay | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 10. | ALA2182699 | B | Inhibition of notch | 17 | assay format | Scientific Literature | |||
| 11. | ALA2182702 | P | Lipophilicity, log D of the compound by RP-HPLC analysis | 27 | small-molecule physicochemical format | Scientific Literature | |||
| 12. | ALA2182703 | B | Selectivity ratio of IC50 for human ERG to IC50 for BACE1 in human SH-SY5Y cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA2182704 | P | Dissociation constant, pKa of the compound by pressure-assisted capillary electrophoretic analysis | 27 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA2182705 | A | Intrinsic clearance in rat hepatocytes assessed per 10'6 cells | Rattus norvegicus | 27 | cell-based format | Scientific Literature | ||
| 15. | ALA2182706 | B | Inhibition of human ERG expressed in CHO cells by IonWorks assay | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 16. | ALA2182707 | A | Efflux ratio of apparent permeability from basal to apical to apical to basal side of human Caco2 cells at 10 uM after 60 mins by LC/MS analysis | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 17. | ALA2182708 | A | Apparent permeability from apical to basal side of human Caco2 cells at 10 uM after 60 mins by LC/MS analysis | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 18. | ALA2183078 | B | Inhibition of BACE1 in human SH-SY5Y cells assessed as inhibition of sAPPbeta release after 16 hrs by immunoassay | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 19. | ALA2183079 | B | Inhibition of human recombinant BACE1 using (europium)CEVNLDAEFK(Qsy7) as substrate incubated for 10 mins prior to substrate addition measured after 15 mins by TR-FRET assay | Homo sapiens | 27 | single protein format | Scientific Literature |
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