# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2187975 | ADME | Plasma protein binding in cynomolgus monkey | Macaca fascicularis | 2 | ALA2176933 | cell-free format | Scientific Literature | |
2. | ALA2187976 | ADME | Clearance in cynomolgus monkey hepatocytes | Macaca fascicularis | 2 | ALA2176933 | cell-based format | Scientific Literature | |
3. | ALA2187977 | Functional | Inhibition of LRRK2 G2019S mutant phosphorylation at Ser1292 in BAC transgenic mouse brain at 10 to 50 mg/kg, ip after 1 to 24 hrs | Mus musculus | 2 | ALA2176933 | organism-based format | Scientific Literature | |
4. | ALA2187978 | Functional | Inhibition of LRRK2 G2019S mutant phosphorylation at Ser1292 in BAC transgenic mouse brain at 10 to 50 mg/kg, po after 1 to 24 hrs | Mus musculus | 2 | ALA2176933 | organism-based format | Scientific Literature | |
5. | ALA2188363 | Binding | Inhibition of recombinant human 5HT2B receptor expressed in CHO cells at 10 uM | Homo sapiens | 2 | ALA2176933 | cell-based format | Scientific Literature | |
6. | ALA2188369 | Binding | Selectivity ratio of Ki for TTK to Ki for LRRK2 | 18 | ALA2176933 | assay format | Scientific Literature | ||
7. | ALA2188374 | ADME | Efflux ratio of permeability from apical to basolateral over basolateral to apical side in MDCK cells expressing human MDR1 | Canis lupus familiaris | 20 | ALA2176933 | cell-based format | Scientific Literature | |
8. | ALA2188375 | ADME | Apparent permeability from apical to basolateral side of MDCK cells expressing human MDR1 | Canis lupus familiaris | 14 | ALA2176933 | cell-based format | Scientific Literature | |
9. | ALA2188376 | ADME | Plasma protein binding in rat | Rattus norvegicus | 14 | ALA2176933 | cell-free format | Scientific Literature | |
10. | ALA2188377 | ADME | Clearance in rat hepatocytes | Rattus norvegicus | 14 | ALA2176933 | cell-based format | Scientific Literature | |
11. | ALA2188378 | ADME | Clearance in human hepatocytes | Homo sapiens | 14 | ALA2176933 | cell-based format | Scientific Literature | |
12. | ALA2188380 | Binding | Selectivity ratio of Ki for JAK2 to Ki for LRRK2 | 18 | ALA2176933 | assay format | Scientific Literature | ||
13. | ALA2188381 | Binding | Inhibition of autophosphorylation of LRRK2 in human HEK293 cells | Homo sapiens | 24 | ALA2176933 | cell-based format | Scientific Literature | |
14. | ALA2188383 | Binding | Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assay | 24 | ALA2176933 | single protein format | Scientific Literature |