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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA2188063 A Cmax in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 2. ALA2188064 A Clearance in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 3. ALA2188065 A Volume of distribution at steady state in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 4. ALA2188066 A Tmax in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 5. ALA2188067 A Half life in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 6. ALA2188068 A AUC (0 to 24 hrs) in Sprague-Dawley rat at 20 mg/kg, po Rattus norvegicus 1 ALA2177100 organism-based format Scientific Literature 7. ALA2188069 F Antitumor activity against human NCI-H1975 cells xenografted in BALB/c mouse assessed as reduction in Ki67 expression at 50 mg/kg/day, po for 10 days by immunohistochemistry Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 8. ALA2188070 F Antitumor activity against human HCC827 cells xenografted in BALB/c mouse assessed as reduction in Ki67 expression at 1 mg/kg/day, po for 3 days by immunohistochemistry Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 9. ALA2188071 F Inhibition of EGFR phosphorylation in human NCI-H1975 cells xenografted in BALB/c mouse at 50 mg/kg/day, po for 10 days by immunohistochemistry Mus musculus 1 ALA2177100 organism-based format Scientific Literature 10. ALA2188072 F Inhibition of EGFR phosphorylation in human HCC827 cells xenografted in BALB/c mouse at 1 mg/kg/day, po for 3 days by immunohistochemistry Mus musculus 1 ALA2177100 organism-based format Scientific Literature 11. ALA2188074 T Toxicity in human NCI-H1975 cells xenografted BALB/c mouse assessed as body weight loss at 50 mg/kg, po qd Mus musculus 1 ALA2177100 organism-based format Scientific Literature 12. ALA2188077 F Antitumor activity against human NCI-H1975 cells xenografted in BALB/c mouse assessed as inhibition of tumor growth administered orally once daily Homo sapiens 1 ALA2177100 cell-based format Scientific Literature 13. ALA2188078 F Antitumor activity against human NCI-H1975 cells xenografted in BALB/c mouse assessed as inhibition of tumor growth at 50 mg/kg, po qd Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 14. ALA2188079 F Antitumor activity against human HCC827 cells xenografted in BALB/c mouse assessed as reduction tumor volume at 20 mg/kg, po qd Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 15. ALA2188080 F Antitumor activity against human HCC827 cells xenografted in BALB/c mouse assessed as reduction tumor volume at 5 mg/kg, po qd Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 16. ALA2188081 F Antitumor activity against human HCC827 cells xenografted in BALB/c mouse assessed as reduction tumor volume at 1 mg/kg, po qd Homo sapiens 1 ALA2177100 organism-based format Scientific Literature 17. ALA2188083 B Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in ERK phosphorylation incubated for 8 hrs by Western blotting method Homo sapiens 1 ALA2177100 cell-based format Scientific Literature 18. ALA2188084 B Inhibition of EGFR in human NCI-H1975 cells assessed as reduction in AKT phosphorylation incubated for 8 hrs by Western blotting method Homo sapiens 1 ALA2177100 cell-based format Scientific Literature 19. ALA2188085 B Inhibition of EGFR phosphorylation in human NCI-H1975 cells incubated for 8 hrs by Western blotting method Homo sapiens 1 ALA2177100 cell-based format Scientific Literature 20. ALA2188086 B Inhibition of EGFR in human HCC827 cells assessed as reduction in ERK phosphorylation incubated for 8 hrs by Western blotting method Homo sapiens 1 ALA2177100 cell-based format Scientific Literature