# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2182758 | B | Thermal stability of c-MYC G-quadruplex DNA assessed as change in melting temperature at DNA:compound ratio 1:1 by spectropolarimeter analysis | 16 | nucleic acid format | Scientific Literature | |||
2. | ALA2182759 | F | Cytotoxicity against human HCT116 cells after 96 hrs by MTS assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
3. | ALA2182760 | F | Cytotoxicity against human Raji cells after 96 hrs by MTS assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
4. | ALA2182762 | B | Binding affinity to HIF1alpha G-quadruplex DNA at 2 uM after 48 hrs by competition dialysis method | 1 | nucleic acid format | Scientific Literature | |||
5. | ALA2182763 | B | Binding affinity to hTERT G-quadruplex DNA at 2 uM after 48 hrs by competition dialysis method | 1 | nucleic acid format | Scientific Literature | |||
6. | ALA2182764 | B | Binding affinity to PDGFRbeta G-quadruplex DNA at 2 uM after 48 hrs by competition dialysis method | 1 | nucleic acid format | Scientific Literature | |||
7. | ALA2182765 | B | Binding affinity to dGdC DNA at 2 uM after 48 hrs by competition dialysis method | 2 | nucleic acid format | Scientific Literature | |||
8. | ALA2182766 | B | Binding affinity to dAdT DNA at 2 uM after 48 hrs by competition dialysis method | 2 | nucleic acid format | Scientific Literature | |||
9. | ALA2182768 | B | Binding affinity to c-MYC G-quadruplex DNA in human HCT116 cells assessed as decrease in c-MYC mRNA expression at 31 uM at 6 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA2182769 | B | Binding affinity to c-MYC G-quadruplex DNA in human HCT116 cells assessed as decrease in c-MYC mRNA expression at 31 uM at 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA2182770 | B | Binding affinity to HIF1alpha G-quadruplex DNA in human HCT116 cells assessed as change in HIF1alpha mRNA expression at 23 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA2182771 | B | Binding affinity to HIF1alpha G-quadruplex DNA in human HCT116 cells assessed as change in HIF1alpha mRNA expression at 31 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA2182773 | B | Binding affinity to hTERT G-quadruplex DNA in human HCT116 cells assessed as downregulation of hTERT mRNA expression at 31 uM at 6 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA2182774 | B | Binding affinity to hTERT G-quadruplex DNA in human HCT116 cells assessed as downregulation of hTERT mRNA expression at 31 uM at 24 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA2182775 | B | Binding affinity to hTERT G-quadruplex DNA in human HCT116 cells assessed as downregulation of hTERT mRNA expression at 31 uM at 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA2182776 | B | Binding affinity to PDGFRbeta G-quadruplex DNA in human HCT116 cells assessed as downregulation of PDGFRbeta mRNA expression at 31 uM at 6 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA2182777 | B | Binding affinity to PDGFRbeta G-quadruplex DNA in human HCT116 cells assessed as downregulation of PDGFRbeta mRNA expression at 31 uM at 24 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA2182778 | B | Binding affinity to PDGFRbeta G-quadruplex DNA in human HCT116 cells assessed as downregulation of PDGFRbeta mRNA expression at 31 uM at 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA2182779 | F | Increase in VEGFA G-quadruplex DNA expression in human HCT116 cells by qPCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA2183150 | B | Decrease of c-MYC G-quadruplex DNA-mediated c-MYC expression in exon1 in human CA46 cells at 2.8 uM at 24 hrs by exon-specific assay | Homo sapiens | 1 | cell-based format | Scientific Literature |