# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2182758 | B | Thermal stability of c-MYC G-quadruplex DNA assessed as change in melting temperature at DNA:compound ratio 1:1 by spectropolarimeter analysis | 16 | nucleic acid format | Scientific Literature | |||
2. | ALA2182759 | F | Cytotoxicity against human HCT116 cells after 96 hrs by MTS assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
3. | ALA2182760 | F | Cytotoxicity against human Raji cells after 96 hrs by MTS assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
4. | ALA2182761 | B | Binding affinity to c-MYC G-quadruplex DNA at 2 uM after 48 hrs by competition dialysis method | 1 | nucleic acid format | Scientific Literature | |||
5. | ALA2182765 | B | Binding affinity to dGdC DNA at 2 uM after 48 hrs by competition dialysis method | 2 | nucleic acid format | Scientific Literature | |||
6. | ALA2182766 | B | Binding affinity to dAdT DNA at 2 uM after 48 hrs by competition dialysis method | 2 | nucleic acid format | Scientific Literature | |||
7. | ALA2182767 | B | Binding affinity to c-MYC G-quadruplex DNA in human HCT116 cells assessed as decrease in c-MYC mRNA expression at 23 uM from 6 to 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA2182770 | B | Binding affinity to HIF1alpha G-quadruplex DNA in human HCT116 cells assessed as change in HIF1alpha mRNA expression at 23 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA2182771 | B | Binding affinity to HIF1alpha G-quadruplex DNA in human HCT116 cells assessed as change in HIF1alpha mRNA expression at 31 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA2182772 | B | Binding affinity to hTERT G-quadruplex DNA in human HCT116 cells assessed as downregulation of hTERT mRNA expression at 23 uM by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA2183148 | B | Binding affinity to PDGFRbeta G-quadruplex DNA in human HCT116 cells assessed as change in PDGFRbeta mRNA expression at 23 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA2183149 | B | Binding affinity to VEGFA G-quadruplex DNA in human HCT116 cells assessed as change in VEGFA mRNA expression at 23 uM up to 48 hrs by RT-PCR analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA2184922 | B | Decrease of c-MYC G-quadruplex DNA-mediated c-MYC expression in exon1 in human CA46 cells at 19.4 uM at 24 hrs by exon-specific assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA2185350 | B | Decrease of c-MYC G-quadruplex DNA-mediated c-MYC expression in exon1 in human CA46 cells at 19.4 uM at 48 hrs by exon-specific assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA2185351 | B | Decrease of c-MYC G-quadruplex DNA-mediated c-MYC expression in exon1 in human CA46 cells at 19.4 uM at 6 hrs by exon-specific assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA2185355 | F | Cytotoxicity against human HCT116 cells after 24 hrs by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA2185356 | F | Cytotoxicity against human CA46 cells after 24 hrs by MTS assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
18. | ALA5105477 | B | Thermal stabilization of c-MYC G4 quadruplex DNA (unknown origin) assessed as melting temperature by spectro-polarimeteric analysis | Not specified | 2 | nucleic acid format | Scientific Literature | ||
19. | ALA5105478 | F | Cytotoxicity against human HCT-116 cells assessed as cell viability by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA5105479 | F | Cytotoxicity against human Raji cells assessed as cell viability by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature |