#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA3816166	Binding	Inhibition of recombinant PI3Kalpha (unknown origin) using dioctanoylglycerol-PIP2 as substrate incubated for 30 mins in presence of TAMRA-PIP3 by fluorescence polarization assay	Homo sapiens	11	ALA3813614	single protein format	Scientific Literature
2.	ALA3816167	Binding	Inhibition of human recombinant mTOR (1360 to 2549 residues) expressed in insect cells assessed as inhibition of GFP-labeled 4-EBP1 phosphorylation at Thr-37/46 residues incubated for 30 mins by FRET assay	Homo sapiens	6	ALA3813614	cell-based format	Scientific Literature
3.	ALA3816168	Functional	Antiproliferative activity against human PC3 cells after 3 days by CellTitre-Glo assay	Homo sapiens	11	ALA3813614	cell-based format	Scientific Literature
4.	ALA3816169	ADME	Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK1 cells expressing human MDR1 at 5 uM incubated for 2 hrs by LC-MS/MS analysis	Canis lupus familiaris	10	ALA3813614	cell-based format	Scientific Literature
5.	ALA3816170	ADME	Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK2 cells expressing mouse BCRP1 at 5 uM incubated for 2 hrs by LC-MS/MS analysis	Canis lupus familiaris	11	ALA3813614	cell-based format	Scientific Literature
6.	ALA3816172	ADME	Ratio of unbound fraction in CD1 mouse brain to plasma at 50 mg/kg, po after 6 hrs by LC-MS/MS analysis	Mus musculus	1	ALA3813614	organism-based format	Scientific Literature
7.	ALA2185131	Functional	Inhibition of PI3Kalpha in PTEN deficient human U87MG cells xenografted in NCr nude mouse assessed as reduction in S6RP phosphorylation at 10 mg/kg, po qd for 24 days measured 1 to 4 hrs post last dose by electrochemiluminescence assay	Mus musculus	2	ALA2177093	organism-based format	Scientific Literature
8.	ALA2185132	Functional	Inhibition of PI3Kalpha in PTEN deficient human U87MG cells xenografted in NCr nude mouse assessed as reduction in S6RP phosphorylation at 40 mg/kg, po qd for 24 days measured 1 to 4 hrs post last dose by electrochemiluminescence assay	Mus musculus	2	ALA2177093	organism-based format	Scientific Literature
9.	ALA2185133	ADME	Drug uptake in NCr nude mouse brain xenografted with PTEN deficient human U87MG cells at 40 mg/kg after 1 hr	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
10.	ALA2185134	ADME	Drug uptake in healthy mouse brain at 50 mg/kg after 1 hr	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
11.	ALA2185825	Binding	Inhibition of PI3KC2beta at 1 uM		1	ALA2177093	single protein format	Scientific Literature
12.	ALA2185828	Functional	Antitumor activity against PTEN deficient human U87MG cells xenografted in NCr nude mouse assessed as inhibition of tumor growth at 3 to 14 mg/kg, po qd for 24 days	Homo sapiens	2	ALA2177093	organism-based format	Scientific Literature
13.	ALA2185829	ADME	Fraction unbound in CD-1 mouse brain at 50 mg/kg, po administered as single dose measured after 6 hrs post dose	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
14.	ALA2185830	ADME	Fraction unbound in CD-1 mouse brain at 50 mg/kg, po administered as single dose measured after 1 hr post dose	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
15.	ALA2185833	ADME	Drug level in CD-1 mouse brain at 50 mg/kg, po administered as single dose measured after 6 hrs post dose	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
16.	ALA2185835	ADME	Drug level in CD-1 mouse brain at 50 mg/kg, po administered as single dose measured after 1 hr post dose	Mus musculus	1	ALA2177093	organism-based format	Scientific Literature
17.	ALA2185837	Binding	Inhibition of PI3Kalpha in human PC3 cells assessed as reduction in pAKT level by immunoblotting method	Homo sapiens	2	ALA2177093	cell-based format	Scientific Literature
18.	ALA2185839	ADME	Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral in mouse Bcrp1 transfected MDCK2 cells at 5 uM after 2 hrs by LC-MS/MS analysis	Canis lupus familiaris	16	ALA2177093	cell-based format	Scientific Literature
19.	ALA2186306	Binding	Inhibition of human recombinant mTOR (1360 to 2549 amino acids) assessed as reduction in phosphorylation of (GFP)-4-EBP1 after 30 mins by FRET assay	Homo sapiens	5	ALA2177093	single protein format	Scientific Literature
20.	ALA2186307	ADME	Clearance in po dosed CD-1 mouse	Mus musculus	4	ALA2177093	organism-based format	Scientific Literature