# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2186423 | Binding | Induction of intrinsic oxidase activity of Trypanosoma brucei TR at 5 uM | Trypanosoma brucei | 5 | ALA2176892 | single protein format | Scientific Literature | |
2. | ALA2186424 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for axenic amastigote form of Leishmania donovani strain MHOM-ET-67/L82 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
3. | ALA2186425 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for promastigote form of Leishmania donovani strain MHOM/SD/00/1S-2D | 12 | ALA2176892 | cell-based format | Scientific Literature | ||
4. | ALA2186426 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for intracellular amastigote form of Trypanosoma cruzi Tulahuen strain C2C4 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
5. | ALA2186427 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for trypomastigote form of Trypanosoma brucei rhodesiense strain STIB 900 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
6. | ALA2186428 | ADME | Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy | Rattus norvegicus | 16 | ALA2176892 | cell-based format | Scientific Literature | |
7. | ALA2186429 | Functional | Antitrypanosomal activity against promastigote form of Leishmania donovani MHOM/SD/00/1S-2D assessed as growth inhibition after 72 hrs by inverted microscopy | Leishmania donovani | 12 | ALA2176892 | organism-based format | Scientific Literature | |
8. | ALA2186430 | Functional | Antitrypanosomal activity against axenic amastigote form of Leishmania donovani MHOM-ET-67/L82 assessed as growth inhibition after 72 hrs by inverted microscopy | Leishmania donovani | 13 | ALA2176892 | organism-based format | Scientific Literature | |
9. | ALA2186431 | Functional | Antitrypanosomal activity against intracellular amastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 92 hrs by inverted microscopy | Trypanosoma cruzi | 13 | ALA2176892 | organism-based format | Scientific Literature | |
10. | ALA2186432 | Functional | Antitrypanosomal activity against trypomastigote form of Trypanosoma brucei rhodesiense STIB 900 assessed as growth inhibition after 72 hrs by microplate fluorometry | Trypanosoma brucei rhodesiense | 13 | ALA2176892 | organism-based format | Scientific Literature | |
11. | ALA2186433 | Binding | Inhibition of Trypanosoma brucei TR using 40 to 100 uM trypanothione disulfide assessed as remaining activity at 5 uM | Trypanosoma brucei | 7 | ALA2176892 | single protein format | Scientific Literature |