# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2185948 | Binding | Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-substrate-inhibitor complex by Lineweaver-Burk plot | Trypanosoma brucei | 2 | ALA2176892 | single protein format | Scientific Literature | |
2. | ALA2185949 | Binding | Mixed type inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide assessed as inhibition constant for enzyme-inhibitor complex by Lineweaver-Burk plot | Trypanosoma brucei | 2 | ALA2176892 | single protein format | Scientific Literature | |
3. | ALA2185950 | Binding | Noncompetitive inhibition of Trypanosoma brucei TR using varying levels of trypanothione disulfide by Lineweaver-Burk plot | Trypanosoma brucei | 1 | ALA2176892 | single protein format | Scientific Literature | |
4. | ALA2185951 | Functional | Potency index, ratio of IC50 for miltefosine to IC50 for compound against axenic amastigote form of Leishmania donovani MHOM-ET-67/L82 assessed as growth inhibition after 72 hrs by inverted microscopy | Leishmania donovani | 1 | ALA2176892 | organism-based format | Scientific Literature | |
5. | ALA2185952 | Functional | Potency index, ratio of IC50 for benznidazole to IC50 for compound against ntracellular amastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 92 hrs by inverted microscopy | Trypanosoma cruzi | 1 | ALA2176892 | organism-based format | Scientific Literature | |
6. | ALA2185953 | Functional | Potency index, ratio of IC50 for melarsoprol to IC50 for compound against trypomastigote form of Trypanosoma brucei rhodesiense STIB 900 assessed as growth inhibition after 72 hrs by microplate fluorometry | Trypanosoma brucei rhodesiense | 1 | ALA2176892 | organism-based format | Scientific Literature | |
7. | ALA2185954 | Functional | Induction of morphological damage in promastigote form of Leishmania donovani MHOM/ET/67/L82 assessed as accumulation of vesicular material inside the flagellar pocket at 5 uM after 4 hrs by transmission electron microscopy | Leishmania donovani | 1 | ALA2176892 | organism-based format | Scientific Literature | |
8. | ALA2185955 | Functional | Reduction in free cytoplasmic ATP level in promastigote form of Leishmania donovani 3-Luc at 2.5 to 25 uM after 15 to 20 mins by luminescence assay | Leishmania donovani | 2 | ALA2176892 | organism-based format | Scientific Literature | |
9. | ALA2185957 | Functional | Reduction in mitochondrial electrochemical potential in promastigote form of Leishmania donovani MHOM/ET/67/L82 assessed as reduction in Rhodamine 123 fluorescence at 25 uM after 4 hrs by flow cytometry | Leishmania donovani | 2 | ALA2176892 | organism-based format | Scientific Literature | |
10. | ALA2186423 | Binding | Induction of intrinsic oxidase activity of Trypanosoma brucei TR at 5 uM | Trypanosoma brucei | 5 | ALA2176892 | single protein format | Scientific Literature | |
11. | ALA2186424 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for axenic amastigote form of Leishmania donovani strain MHOM-ET-67/L82 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
12. | ALA2186425 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for promastigote form of Leishmania donovani strain MHOM/SD/00/1S-2D | 12 | ALA2176892 | cell-based format | Scientific Literature | ||
13. | ALA2186426 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for intracellular amastigote form of Trypanosoma cruzi Tulahuen strain C2C4 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
14. | ALA2186427 | Toxicity | Selectivity index, ratio of IC50 for rat L6 cells to IC50 for trypomastigote form of Trypanosoma brucei rhodesiense strain STIB 900 | 13 | ALA2176892 | cell-based format | Scientific Literature | ||
15. | ALA2186428 | ADME | Cytotoxicity against rat L6 cells assessed as growth inhibition after 72 hrs by inverted microscopy | Rattus norvegicus | 16 | ALA2176892 | cell-based format | Scientific Literature | |
16. | ALA2186429 | Functional | Antitrypanosomal activity against promastigote form of Leishmania donovani MHOM/SD/00/1S-2D assessed as growth inhibition after 72 hrs by inverted microscopy | Leishmania donovani | 12 | ALA2176892 | organism-based format | Scientific Literature | |
17. | ALA2186430 | Functional | Antitrypanosomal activity against axenic amastigote form of Leishmania donovani MHOM-ET-67/L82 assessed as growth inhibition after 72 hrs by inverted microscopy | Leishmania donovani | 13 | ALA2176892 | organism-based format | Scientific Literature | |
18. | ALA2186431 | Functional | Antitrypanosomal activity against intracellular amastigote form of Trypanosoma cruzi Tulahuen C2C4 infected in rat L6 cells assessed as growth inhibition after 92 hrs by inverted microscopy | Trypanosoma cruzi | 13 | ALA2176892 | organism-based format | Scientific Literature | |
19. | ALA2186432 | Functional | Antitrypanosomal activity against trypomastigote form of Trypanosoma brucei rhodesiense STIB 900 assessed as growth inhibition after 72 hrs by microplate fluorometry | Trypanosoma brucei rhodesiense | 13 | ALA2176892 | organism-based format | Scientific Literature | |
20. | ALA2186433 | Binding | Inhibition of Trypanosoma brucei TR using 40 to 100 uM trypanothione disulfide assessed as remaining activity at 5 uM | Trypanosoma brucei | 7 | ALA2176892 | single protein format | Scientific Literature |