# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2185364 | F | Inhibition of RAGE-mediated influx of human amyloid beta (1 to 42) into ICR mouse brain at 25 mg/kg, ip administered 20 mins prior to human amyloid beta (1 to 40)-injection measured after 30 mins by ELISA relative to control | Mus musculus | 3 | ALA2176979 | organism-based format | Scientific Literature | |
2. | ALA2185365 | A | Cytotoxicity against rat C6 cells at 0.1 to 10 uM after 18 hrs | Rattus norvegicus | 3 | ALA2176979 | cell-based format | Scientific Literature | |
3. | ALA2185366 | B | Inhibition of receptor for advanced glycation end product binding to amyloid beta 42 in rat C6 cells assessed as NFkappaB activation at 0.1 to 10 uM after 18 hrs by reporter gene assay | Rattus norvegicus | 3 | ALA2176979 | cell-based format | Scientific Literature | |
4. | ALA2185368 | B | Inhibition of human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 assessed as inhibition of binding to amyloid beta (1 to 42) at 20 uM after 60 mins by TMB-ELISA | Homo sapiens | 39 | ALA2176979 | assay format | Scientific Literature | |
5. | ALA2185369 | F | Reduction in human amyloid beta (1 to 42) level in ICR mouse plasma at 25 mg/kg, ip administered 20 mins prior to human amyloid beta (1 to 40)-injection measured after 30 mins by ELISA relative to control | Mus musculus | 3 | ALA2176979 | organism-based format | Scientific Literature |