| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2185357 | B | Binding affinity to human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 after 1 min by surface plasmon resonance assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 2. | ALA2185358 | T | Toxicity against transgenic mouse expressing PS1/APP swedish mutant assessed as lethality at 50 mg/kg/day, po administered for 3 months measured after 2 months | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 3. | ALA2185359 | F | Procognitive activity in transgenic mouse expressing PS1/APP swedish mutant assessed as spontaneous alteration at 50 mg/kg/day, po administered for 3 months measured after 2 months by Y maze test (Rvb = 50.95 +/- 10.8%) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2185360 | F | Antialzheimer activity in transgenic mouse expressing PS1/APP swedish mutant assessed as insoluble amyloid beta (1 to 42) level per mg of protein in brain at 50 mg/kg/day, po for 3 months by ELISA (Rvb = 513.73 +/- 219.56 ng per mg of protein) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2185361 | F | Antialzheimer activity in transgenic mouse expressing PS1/APP swedish mutant assessed as soluble amyloid beta (1 to 42) level per mg of protein in brain at 50 mg/kg/day, po for 3 months by ELISA (Rvb = 17.34 +/- 5.17 ng per mg of protein) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2185362 | F | Antialzheimer activity in transgenic mouse expressing PS1/APP swedish mutant assessed as insoluble amyloid beta (1 to 40) level per mg of protein in brain at 50 mg/kg/day, po for 3 months by ELISA (Rvb = 137.38+/- 58.13 ng per mg of protein) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA2185363 | F | Antialzheimer activity in transgenic mouse expressing PS1/APP swedish mutant assessed as soluble amyloid beta (1 to 40) level per mg of protein in brain at 50 mg/kg/day, po for 3 months by ELISA (Rvb = 8.66 +/- 1.81 ng per mg of protein) | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA2185364 | F | Inhibition of RAGE-mediated influx of human amyloid beta (1 to 42) into ICR mouse brain at 25 mg/kg, ip administered 20 mins prior to human amyloid beta (1 to 40)-injection measured after 30 mins by ELISA relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 9. | ALA2185365 | A | Cytotoxicity against rat C6 cells at 0.1 to 10 uM after 18 hrs | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA2185366 | B | Inhibition of receptor for advanced glycation end product binding to amyloid beta 42 in rat C6 cells assessed as NFkappaB activation at 0.1 to 10 uM after 18 hrs by reporter gene assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA2185367 | B | Inhibition of human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 assessed as inhibition of binding to amyloid beta (1 to 42) after 60 mins by TMB-ELISA | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 12. | ALA2185368 | B | Inhibition of human recombinant biotinylated receptor for advanced glycation end product expressed in Escherichia coli DE3 assessed as inhibition of binding to amyloid beta (1 to 42) at 20 uM after 60 mins by TMB-ELISA | Homo sapiens | 39 | assay format | Scientific Literature | ||
| 13. | ALA2185369 | F | Reduction in human amyloid beta (1 to 42) level in ICR mouse plasma at 25 mg/kg, ip administered 20 mins prior to human amyloid beta (1 to 40)-injection measured after 30 mins by ELISA relative to control | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA3243670 | A | AUC in Sprague-Dawley rat at 2 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4030325 | B | Inhibition of amyloid beta binding to biotin-labeled human RAGE domain V after 60 mins by ELISA | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 16. | ALA4030326 | A | Cytotoxicity against mouse HT22 cells assessed as cell survival at 10 uM after 18 hrs by MTT assay relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA5165149 | B | Inhibition of biotinylated human RAGE/amyloid beta interaction incubated for 120 mins by ELISA assay | Homo sapiens | 37 | single protein format | Scientific Literature |
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