| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2184092 | T | Toxicity in Trp1455/9M peptide immunized C57BL/6 mouse at 50 ug measured after 34 of immunization | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA2184093 | F | Immunomodulatory activity in Trp1455/9M peptide immunized C57BL/6 mouse assessed as Trp1455/9M specific CD8+ T cells in blood at 50 ug using Trp1455/9M/ H-2Db staining measured after 34 of immunization by FACS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 3. | ALA2184094 | F | Immunomodulatory activity in Trp1455/9M peptide immunized C57BL/6 mouse assessed as Trp1455/9M specific CD8+ T cells in blood at 50 ug using Trp1455/9M/ H-2Db staining measured after 21 of immunization by FACS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 4. | ALA2184095 | F | Immunomodulatory activity in Trp1455/9M peptide immunized C57BL/6 mouse assessed as Trp1455/9M specific CD8+ T cells in blood at 50 ug using Trp1455/9M/ H-2Db staining measured after 7 of immunization by FACS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA2184100 | F | Agonist activity at human TLR2 expressed in HEK293 cells assessed as induction of NF-kappaB signaling after 24 hrs by luminescence based luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA2184101 | F | Agonist activity at human TLR2 expressed in HEK293 cells assessed as induction of NF-kappaB signaling after 24 hrs by luminescence based luciferase reporter gene assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 7. | ALA3820861 | B | Agonist activity at human TLR2 expressed in HEK cells assessed as increase in IL-8 production at 100 ng/ml incubated for 24 hrs by ELISA | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4433999 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4434004 | A | Effect on IL-6 mRNA expression in TLR2-/- mouse BMDM cells at 0.1 to 1 uM by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4434005 | B | Agonist activity at TLR2 in wild type mouse BMDM cells assessed as induction of NFkappaB pathway activation by measuring increase in IL-6 mRNA expression by qRT-PCR analysis | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4434006 | B | Agonist activity at TLR2 in mouse dendritic cells assessed as upregulation CD80 expression at 100 ng/ml by flow cytometry | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4434014 | B | Agonist activity at TLR2/1 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR1-IGG for 2 hrs by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4434015 | B | Agonist activity at TLR2/6 in PMA-differentiated human THP-1 cells assessed as induction of IL-6 production at 2.5 uM incubated for 24 hrs after preincubation with anti-hTLR6-IGG for 2 hrs by ELISA | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4434021 | F | Effect on IL-12 production in TLR2-/- mouse BMDM cells at 0.1 to 1 uM incubated for 24 hrs by ELISA | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA5105455 | B | Agonist activity at human TLR2/TLR6 expressed in HEK-Blue hTLR2-TLR6 cells by SEAP reporter gene based Quanti-blue assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 16. | ALA5105456 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-6 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 17. | ALA5105457 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in IL-10 production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 18. | ALA5105458 | B | Agonist activity at TLR2/TLR6 in human PBMC cells assessed as increase in TNF-alpha production at 0.1 ug/ml incubated for 24 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 19. | ALA5105459 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD40 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 6 | tissue-based format | Scientific Literature | ||
| 20. | ALA5105460 | B | Agonist activity at TLR2/TLR6 in C57BL/6 mouse spleen B cells assessed as increase in CD86 expression at 10 to 0.1 ug/ml incubated for 24 hrs by fluorescence based flow cytometric analysis | Mus musculus | 3 | tissue-based format | Scientific Literature |
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