# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2184666 | F | Procognitive activity in Sprague-Dawley rat assessed as recognition index at 0.1 mg/kg, po administered QD for 3 days 30 mins prior to testing by novel object recognition test (Rvb = 50%) | Rattus norvegicus | 1 | ALA2176988 | organism-based format | Scientific Literature | |
2. | ALA2184667 | F | Procognitive activity in Sprague-Dawley rat assessed as increase in working memory at 0.1 to 0.3 mg/kg, po administered QD for 3 days 30 mins prior to testing by novel object recognition test | Rattus norvegicus | 1 | ALA2176988 | organism-based format | Scientific Literature | |
3. | ALA2184668 | A | Inhibition of CYP2D6 | 2 | ALA2176988 | single protein format | Scientific Literature | ||
4. | ALA2184669 | B | Inhibition of human ERG at 10 uM | Homo sapiens | 2 | ALA2176988 | single protein format | Scientific Literature | |
5. | ALA2184671 | B | Inhibition of human 5HT3 receptor | Homo sapiens | 1 | ALA2176988 | single protein format | Scientific Literature | |
6. | ALA2184673 | B | Inhibition of human 5HT3 receptor at 10 uM | Homo sapiens | 1 | ALA2176988 | single protein format | Scientific Literature | |
7. | ALA2184674 | B | Inhibition of mouse 5HT3 receptor at 10 uM | Mus musculus | 1 | ALA2176988 | single protein format | Scientific Literature | |
8. | ALA2184675 | F | Agonist activity at ganglion nAChR | 2 | ALA2176988 | assay format | Scientific Literature | ||
9. | ALA2184676 | F | Agonist activity at alpha1beta1gammadelta nAChR | 2 | ALA2176988 | assay format | Scientific Literature | ||
10. | ALA2184681 | F | Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium flux by calcium4-based FLIPR assay relative to nicotine | Homo sapiens | 59 | ALA2176988 | cell-based format | Scientific Literature | |
11. | ALA2184682 | F | Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium flux by calcium4-based FLIPR assay | Homo sapiens | 60 | ALA2176988 | cell-based format | Scientific Literature | |
12. | ALA2184683 | F | Agonist activity at alpha4beta2 nAChR in human SH-EP1 cells assessed as calcium flux by calcium4-based FLIPR assay relative to nicotine | Homo sapiens | 45 | ALA2176988 | cell-based format | Scientific Literature | |
13. | ALA2184684 | F | Agonist activity at alpha4beta2 nAChR in human SH-EP1 cells assessed as calcium flux by calcium4-based FLIPR assay | Homo sapiens | 46 | ALA2176988 | cell-based format | Scientific Literature | |
14. | ALA2184685 | B | Displacement of [3H]epibatidine from human alpha7 nAChR expressed in CHO cells after 2 hrs by liquid scintillation counting | Homo sapiens | 60 | ALA2176988 | cell-based format | Scientific Literature | |
15. | ALA2184686 | B | Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in CHO cells after 2 hrs by liquid scintillation counting | Homo sapiens | 58 | ALA2176988 | cell-based format | Scientific Literature | |
16. | ALA2185121 | B | Displacement of [3H]epibatidine from alpha4beta2 nAChR in Sprague-Dawley rat cortex after 2 hrs by liquid scintillation counting | Rattus norvegicus | 60 | ALA2176988 | assay format | Scientific Literature | |
17. | ALA2185122 | B | Displacement of [3H]nicotine from alpha4beta2 nAChR in human SH-EP1 cells after 2 hrs by liquid scintillation assay | Homo sapiens | 60 | ALA2176988 | cell-based format | Scientific Literature | |
18. | ALA2410168 | B | Agonist activity at human alpha3beta4 nACHR expressed in CHO cell membranes assessed as stimulation of calcium flux by FLIPR assay relative to control | Homo sapiens | 36 | ALA2407030 | cell-based format | Scientific Literature | |
19. | ALA2410349 | B | Agonist activity at human alpha3beta4 nACHR expressed in CHO cell membranes assessed as stimulation of calcium flux by FLIPR assay | Homo sapiens | 36 | ALA2407030 | cell-based format | Scientific Literature | |
20. | ALA2410350 | B | Agonist activity at alpha4beta2 nACHR in human SHEP1 cell membranes assessed as stimulation of calcium flux by FLIPR assay | Homo sapiens | 36 | ALA2407030 | cell-based format | Scientific Literature |