# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2183974 | Binding | Selectivity index, ratio of EC50 for rat mGlu8R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
2. | ALA2183975 | Binding | Selectivity index, ratio of EC50 for rat mGlu7R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
3. | ALA2183976 | Binding | Selectivity index, ratio of EC50 for rat mGlu6R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
4. | ALA2183977 | Binding | Selectivity index, ratio of EC50 for rat mGlu5R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
5. | ALA2183978 | Binding | Selectivity index, ratio of EC50 for rat mGlu4R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
6. | ALA2183979 | Binding | Selectivity index, ratio of EC50 for rat mGlu3R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
7. | ALA2183980 | Binding | Selectivity index, ratio of EC50 for rat mGlu1R to EC50 for rat mGlu2R | Rattus norvegicus | 3 | ALA2177081 | assay format | Scientific Literature | |
8. | ALA2183982 | Functional | Agonist activity at rat mGlu8R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 3 | ALA2177081 | cell-based format | Scientific Literature | |
9. | ALA2184412 | Functional | Agonist activity at rat mGlu7R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 2 | ALA2177081 | cell-based format | Scientific Literature | |
10. | ALA2184413 | Functional | Agonist activity at rat mGlu6R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 3 | ALA2177081 | cell-based format | Scientific Literature | |
11. | ALA2184414 | Functional | Agonist activity at rat mGlu5R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assay | Rattus norvegicus | 3 | ALA2177081 | cell-based format | Scientific Literature | |
12. | ALA2184415 | Functional | Agonist activity at rat mGlu4R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 3 | ALA2177081 | cell-based format | Scientific Literature | |
13. | ALA2184416 | Functional | Agonist activity at rat mGlu3R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 2 | ALA2177081 | cell-based format | Scientific Literature | |
14. | ALA2184417 | Functional | Agonist activity at rat mGlu1R expressed in HEK293 cells co-expressing GIRK channels by calcium flux assay | Rattus norvegicus | 3 | ALA2177081 | cell-based format | Scientific Literature | |
15. | ALA2184418 | ADME | Stability in rat liver microsomes assessed as compound remaining at 4 uM incubated for 1 hr at 37 degC by LC/MS method | Rattus norvegicus | 25 | ALA2177081 | microsome format | Scientific Literature | |
16. | ALA2184419 | ADME | Stability in rat plasma assessed as compound remaining at 100 uM incubated for 1 hr at 37 degC by LC/MS method | Rattus norvegicus | 25 | ALA2177081 | cell-free format | Scientific Literature | |
17. | ALA2184420 | ADME | Permeability of the compound at 100 uM at pH 7.4 by PAMPA assay | 25 | ALA2177081 | assay format | Scientific Literature | ||
18. | ALA2184421 | Binding | Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay relative to glutamate | Rattus norvegicus | 25 | ALA2177081 | cell-based format | Scientific Literature | |
19. | ALA2184422 | Binding | Positive allosteric modulation activity at rat mGlu2R expressed in HEK293 cells co-expressing GIRK channels by thallium flux assay | Rattus norvegicus | 30 | ALA2177081 | cell-based format | Scientific Literature |