| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2187447 | F | Receptor occupancy at PDE10 in sc dosed Wistar rat after 30 mins by beta-imaging analysis | Rattus norvegicus | 1 | ALA2177053 | organism-based format | Scientific Literature | |
| 2. | ALA2187448 | B | Selectivity ratio of IC50 for PDE1B1 to IC50 for rat recombinant PDE10A2 | 3 | ALA2177053 | assay format | Scientific Literature | ||
| 3. | ALA2187449 | B | Inhibition of rat recombinant PDE10A2 expressed in baculovirus infected SF21 cells using [3H]cAMP as substrate after 60 mins by scintillation proximity assay | Rattus norvegicus | 3 | ALA2177053 | cell-based format | Scientific Literature | |
| 4. | ALA2182996 | F | Antipsychotic activity in sc dosed Wiga rat assessed as inhibition of phencyclidine-induced hyperlocomotion administered 60 mins prior to phencyclidine challenge measured up to 30 mins | Rattus norvegicus | 3 | ALA2177053 | organism-based format | Scientific Literature | |
| 5. | ALA2182997 | F | Antipsychotic activity in sc dosed Wistar Wiga rat assessed as latency to avoid an electric shock measured up to 120 mins by conditioned avoidance responce test | Rattus norvegicus | 3 | ALA2177053 | organism-based format | Scientific Literature | |
| 6. | ALA3396559 | B | Inhibition of rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP substrate incubated for 60 mins by topcount scintillation counting method | Rattus norvegicus | 34 | ALA3393008 | cell-based format | Scientific Literature | |
| 7. | ALA3396560 | A | Intrinsic clearance in rat liver microsomes at 1 uM after 5 to 60 mins | Rattus norvegicus | 27 | ALA3393008 | assay format | Scientific Literature | |
| 8. | ALA3396561 | A | Hepatic extraction ratio in rat liver microsomes at 1 uM after 5 to 60 mins | Rattus norvegicus | 27 | ALA3393008 | assay format | Scientific Literature | |
| 9. | ALA3396562 | F | Inhibition of apomorphine-induced stereotypy in Wistar rat pre-treated with test compound dosed subcutaneously 30 mins before apomorphine challenge and measured every 5 mins over first hour after injection of apomorphine | Rattus norvegicus | 13 | ALA3393008 | organism-based format | Scientific Literature | |
| 10. | ALA3396564 | F | In-vivo occupancy at PDE10A in subcutaneously dosed Wistar rat assessed as inhibition of [3H]MP-10 binding measured after 1 hr post dose by digital autoradiography | Rattus norvegicus | 5 | ALA3393008 | organism-based format | Scientific Literature | |
| 11. | ALA3396643 | B | Selectivity index, ratio of pIC50 for PDE1B (unknown origin) to pIC50 for rat recombinant PDE10A | 1 | ALA3393008 | assay format | Scientific Literature | ||
| 12. | ALA3396644 | A | Inhibition of CYP450 (unknown origin) | Homo sapiens | 1 | ALA3393008 | assay format | Scientific Literature | |
| 13. | ALA3396645 | A | Protein binding in human plasma | Homo sapiens | 1 | ALA3393008 | cell-free format | Scientific Literature | |
| 14. | ALA3396646 | A | Protein binding in rat plasma | Rattus norvegicus | 1 | ALA3393008 | cell-free format | Scientific Literature | |
| 15. | ALA3396647 | A | Protein binding in human brain | Homo sapiens | 1 | ALA3393008 | tissue-based format | Scientific Literature | |
| 16. | ALA3396648 | A | Protein binding in rat brain | Rattus norvegicus | 1 | ALA3393008 | tissue-based format | Scientific Literature | |
| 17. | ALA3396649 | A | Oral bioavailability in rat at 10 mg/kg administered as single dose | Rattus norvegicus | 1 | ALA3393008 | organism-based format | Scientific Literature | |
| 18. | ALA3396650 | A | Clearance in rat | Rattus norvegicus | 1 | ALA3393008 | organism-based format | Scientific Literature | |
| 19. | ALA3396651 | A | Volume of distribution in rat | Rattus norvegicus | 1 | ALA3393008 | organism-based format | Scientific Literature | |
| 20. | ALA3396652 | A | Terminal half life in rat | Rattus norvegicus | 1 | ALA3393008 | organism-based format | Scientific Literature |
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