Toxicity in Nu-Foxn1'nu mouse assessed as effect on motor coordination at 10 mg/kg, po administered once daily on day 1 to 10, day 15 to 19 and day 22 to 26 measured during day 58 to 61 post dose by rotarod test
Toxicity in Nu-Foxn1'nu mouse assessed as effect on motor coordination at 5 mg/kg, po administered once daily on day 1 to 10, day 15 to 19 and day 22 to 26 measured during day 58 to 61 post dose by rotarod test
Toxicity in human A549 cells xenografted Nu-Foxn1'nu mouse assessed as incidence of overt toxicity at 10 mg/kg, po administered once daily on day 1 to 10, day 15 to 19 and day 22 to 26
Antitumor activity against human A549 cells xenografted in Nu-Foxn1'nu mouse assessed as reduction in tumor volume at 10 mg/kg, po administered once daily on day 1 to 10, day 15 to 19 and day 22 to 26
Antiviral activity against Murine hepatitis virus JHM infected in mouse DBT cells assessed as reduction in N-protein expression at 0.05 to 0.5 uM pre-treated 1 hr before virus infection and measured 24 hrs post infection by immunofluorescent assay