| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2185504 | B | Inhibition of gamma secretase expressed in human H4 cells expressing BRI-C99 fusion protein assessed as C99 fragment accumulation fragment at 10 uM incubated for 16 hrs in by immunoblot | Homo sapiens | 6 | ALA2176894 | cell-based format | Scientific Literature | |
| 2. | ALA2185507 | B | Inhibition of BACE1 expressed in human H4 cells assessed as reduction in sAPPbeta level at 10 uM incubated for 16 hrs in presence of 25 uM metalloprotease inhibitor batimastat by HPLAP-APP reporter assay | Homo sapiens | 14 | ALA2176894 | cell-based format | Scientific Literature | |
| 3. | ALA2185511 | B | Selectivity index, ratio of IC50 for cathepsin D to IC50 for cathepsin E | 17 | ALA2176894 | assay format | Scientific Literature | ||
| 4. | ALA2185512 | B | Inhibition of cathepsin E by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
| 5. | ALA2185513 | B | Inhibition of cathepsin D by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
| 6. | ALA2185514 | B | Inhibition of BACE1 by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
| 7. | ALA3816585 | B | Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 120 mins by fluorescence analysis | Homo sapiens | 3 | ALA3813591 | assay format | Scientific Literature | |
| 8. | ALA3816586 | B | Inhibition of human recombinant cathepsin E using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 120 mins by fluorescence analysis | Homo sapiens | 3 | ALA3813591 | single protein format | Scientific Literature | |
| 9. | ALA3816587 | B | Selectivity ratio of IC50 for human liver cathepsin D to IC50 for human recombinant cathepsin E | Homo sapiens | 3 | ALA3813591 | assay format | Scientific Literature | |
| 10. | ALA3816588 | B | Inhibition of BACE1 (unknown origin) using peptide substrate by time-course measurement-based fluorescence analysis | Homo sapiens | 3 | ALA3813591 | single protein format | Scientific Literature | |
| 11. | ALA3817349 | B | Selectivity ratio of IC50 for BACE1 (unknown origin) to IC50 for human liver cathepsin D | Homo sapiens | 2 | ALA3813591 | assay format | Scientific Literature | |
| 12. | ALA3817350 | B | Selectivity ratio of IC50 for BACE1 (unknown origin) to IC50 for human recombinant cathepsin E | Homo sapiens | 2 | ALA3813591 | assay format | Scientific Literature | |
| 13. | ALA5158466 | B | Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 10 | ALA5154724 | assay format | Scientific Literature | |
| 14. | ALA5158467 | B | Inhibition of Cathepsin E (unknown origin) using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 9 | ALA5154724 | single protein format | Scientific Literature | |
| 15. | ALA5158468 | B | Inhibition of BACE1 (unknown origin) using Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 8 | ALA5154724 | single protein format | Scientific Literature |
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