# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2185504 | B | Inhibition of gamma secretase expressed in human H4 cells expressing BRI-C99 fusion protein assessed as C99 fragment accumulation fragment at 10 uM incubated for 16 hrs in by immunoblot | Homo sapiens | 6 | ALA2176894 | cell-based format | Scientific Literature | |
2. | ALA2185507 | B | Inhibition of BACE1 expressed in human H4 cells assessed as reduction in sAPPbeta level at 10 uM incubated for 16 hrs in presence of 25 uM metalloprotease inhibitor batimastat by HPLAP-APP reporter assay | Homo sapiens | 14 | ALA2176894 | cell-based format | Scientific Literature | |
3. | ALA2185511 | B | Selectivity index, ratio of IC50 for cathepsin D to IC50 for cathepsin E | 17 | ALA2176894 | assay format | Scientific Literature | ||
4. | ALA2185512 | B | Inhibition of cathepsin E by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
5. | ALA2185513 | B | Inhibition of cathepsin D by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
6. | ALA2185514 | B | Inhibition of BACE1 by fluorescence assay | 18 | ALA2176894 | single protein format | Scientific Literature | ||
7. | ALA3406368 | B | Inhibition of BACE1 (unknown origin) after 90 mins by fluorescence assay | Homo sapiens | 22 | ALA3400120 | single protein format | Scientific Literature | |
8. | ALA5158466 | B | Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 10 | ALA5154724 | assay format | Scientific Literature | |
9. | ALA5158467 | B | Inhibition of Cathepsin E (unknown origin) using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 9 | ALA5154724 | single protein format | Scientific Literature | |
10. | ALA5158468 | B | Inhibition of BACE1 (unknown origin) using Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay | Homo sapiens | 8 | ALA5154724 | single protein format | Scientific Literature | |
11. | ALA5158469 | F | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay | Homo sapiens | 5 | ALA5154724 | cell-based format | Scientific Literature | |
12. | ALA5158470 | F | Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay | Homo sapiens | 5 | ALA5154724 | cell-based format | Scientific Literature | |
13. | ALA5158471 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by CCK-8 assay | Homo sapiens | 5 | ALA5154724 | cell-based format | Scientific Literature | |
14. | ALA5158472 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability at 10 uM after 72 hrs by CCK-8 assay relative to control | Homo sapiens | 5 | ALA5154724 | cell-based format | Scientific Literature |