| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2187734 | F | Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay | Homo sapiens | 40 | ALA2177042 | cell-based format | Scientific Literature | |
| 2. | ALA2439687 | B | Agonist activity at TGR5 (unknown origin) | Homo sapiens | 1 | ALA2434932 | single protein format | Scientific Literature | |
| 3. | ALA4839233 | F | Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay | Homo sapiens | 36 | ALA4837241 | cell-based format | Scientific Literature | |
| 4. | ALA4839237 | B | Agonist activity at N-terminal HA-tagged dog TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay relative to control | Canis lupus familiaris | 4 | ALA4837241 | cell-based format | Scientific Literature | |
| 5. | ALA4839239 | B | Ratio of agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells to agonist activity at N-terminal HA-tagged mouse TGR5 H88Y mutant expressed in HEK293 cells | Mus musculus | 3 | ALA4837241 | cell-based format | Scientific Literature | |
| 6. | ALA5247720 | P | Aqueous solubility of compound | 3 | ALA5247574 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA5247721 | A | Clearance in mouse liver microsomes | Mus musculus | 2 | ALA5247574 | microsome format | Scientific Literature | |
| 8. | ALA5247722 | B | Agonist activity at human TGR5 relative to LCA | Homo sapiens | 1 | ALA5247574 | single protein format | Scientific Literature | |
| 9. | ALA5247723 | B | Agonist activity at mouse TGR5 | Mus musculus | 3 | ALA5247574 | single protein format | Scientific Literature | |
| 10. | ALA5247724 | B | Agonist activity at human TGR5 | Homo sapiens | 5 | ALA5247574 | single protein format | Scientific Literature | |
| 11. | ALA5247732 | A | Clearance in human liver microsomes | Homo sapiens | 2 | ALA5247574 | microsome format | Scientific Literature | |
| 12. | ALA5253209 | A | Clearance in mouse microsomes | Mus musculus | 5 | ALA5252517 | microsome format | Scientific Literature | |
| 13. | ALA5253210 | A | Clearance in human microsomes | Homo sapiens | 5 | ALA5252517 | microsome format | Scientific Literature | |
| 14. | ALA5253211 | P | Aqueous solubility of the compound in lyophilized phosphate buffer at pH 6.5 by spectrophotometric analysis | 5 | ALA5252517 | small-molecule physicochemical format | Scientific Literature | ||
| 15. | ALA5253212 | P | Lipophilicity, log D of the compound in Octanol/TAPSO buffer at pH 7.4 by spectrophotometric analysis | 5 | ALA5252517 | small-molecule physicochemical format | Scientific Literature | ||
| 16. | ALA5253214 | B | Agonist activity at GPBAR1 in human NCI-H716 cells | Homo sapiens | 5 | ALA5252517 | cell-based format | Scientific Literature |
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