# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2188784 | A | Half life in human serum at 40 mM by HPLC | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
2. | ALA2188788 | F | Agonist activity at turkey P2Y1R expressed in 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry | Meleagris gallopavo | 7 | cell-based format | Scientific Literature | ||
3. | ALA2188792 | P | Half life in Tris buffer at pH 9.8 at 0.2 mg by HPLC in presence of alkaline phosphatase | 6 | small-molecule physicochemical format | Scientific Literature | |||
4. | ALA2182177 | A | Stability of the compound assessed as human eNPP1-mediated degradation of compound measuring increase in NMP level at pH 8.5 at 0.2 mM after 20 mins by HPLC relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
5. | ALA2182180 | F | Antiplatelet activity in Balb/c mouse assessed as inhibition of ADP-induced aggregation measuring prolongation of bleeding time at 30 mg/kg body weight, iv | Mus musculus | 2 | organism-based format | Scientific Literature | ||
6. | ALA2182181 | F | Antidiabetic activity in db+/db- diabetic mouse model assessed as reduction in blood glucose level at 30 mg/kg body weight, iv administered 10 min post glucose challenge measured over 15 to 120 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
7. | ALA2182182 | F | Antagonist activity at human P2Y12R expressed in U-205 cells assessed as intracellular calcium level in presence of ADP | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA2182183 | F | Antiplatelet activity in Lewis rat assessed as inhibition of ADP-induced aggregation measuring prolongation in bleeding time at 30 mg/kg body weight, po administered 30 mins prior to tail incision measured after 5 mins | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
9. | ALA2182184 | F | Antiplatelet activity in Balb/c mouse assessed as inhibition of ADP-induced aggregation measuring prolongation in bleeding time at 30 mg/kg body weight, iv administered prior to tail incision measured after 5 mins relative to active clopidogrel metabolite R-361015 | Mus musculus | 1 | organism-based format | Scientific Literature | ||
10. | ALA2182185 | F | Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation at 0.3 to 10 uM measured after 6 mins by aggregometry relative to control | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
11. | ALA2182186 | F | Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation measured after 6 mins by aggregometry | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
12. | ALA2182187 | F | Antidiabetic activity in STZ treated fasted ICR mouse assessed as reduction in blood glucose level at 30 mg/kg body weight, iv administered 10 min post glucose challenge measured over 15 to 120 mins | Mus musculus | 1 | organism-based format | Scientific Literature | ||
13. | ALA2182190 | F | Antidiabetic activity in overnight fasted Wister Han rat assessed as reduction in blood glucose level at 30 mg/kg body weight, iv administered 10 mins post glucose challenge measured within 45 mins (Rvb = 155 mg/dl) | Rattus norvegicus | 1 | organism-based format | Scientific Literature |