# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2208948 | Binding | Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol after 24 hrs by thin layer chromatography | Homo sapiens | 5 | ALA2203102 | cell-based format | Scientific Literature | |
2. | ALA2208949 | ADME | Estrogenic activity in estrogen-starved estrogen sensitive human MCF7 cells assessed as stimulation of cell proliferation at 0.1 to 1 uM after 7 days by CellTiter96 assay | Homo sapiens | 1 | ALA2203102 | cell-based format | Scientific Literature | |
3. | ALA2208950 | Binding | Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol at 0.1 uM after 24 hrs by thin layer chromatography | Homo sapiens | 5 | ALA2203102 | cell-based format | Scientific Literature | |
4. | ALA2208951 | Binding | Inhibition of 17beta-HSD1 in human T47D cells assessed as decrease in transformation of [14C]estrone to [14C]-estradiol at 0.01 uM after 24 hrs by thin layer chromatography | Homo sapiens | 5 | ALA2203102 | cell-based format | Scientific Literature | |
5. | ALA3110999 | Binding | Competitive inhibition of 17-beta HSD1 (unknown origin) using [14C]E1/E1 as substrate assessed as transformation of [14C]E1 to [14C]E2 at 0.1 to 0.5 uM after 45 mins by thin layer chromatography | Homo sapiens | 1 | ALA3108749 | single protein format | Scientific Literature | |
6. | ALA3111000 | Binding | Irreversible inhibition of 17-beta HSD1 (unknown origin) using [14C]E1 as substrate at 0.1 to 0.5 uM after 45 mins by thin layer chromatography | Homo sapiens | 1 | ALA3108749 | single protein format | Scientific Literature | |
7. | ALA3111001 | Binding | Inhibition of 17-beta HSD1 (unknown origin) using [14C]E1 as substrate at 0.1 to 0.5 uM by thin layer chromatography | Homo sapiens | 1 | ALA3108749 | single protein format | Scientific Literature | |
8. | ALA3111002 | ADME | Inhibition of CYP3A4 (unknown origin) by fluorescence assay | Homo sapiens | 3 | ALA3108749 | single protein format | Scientific Literature | |
9. | ALA3111003 | Binding | Inhibition of 17-beta HSD12 (unknown origin) transfected in HEK293 cells using [14C]E1 as substrate at 10 uM | Homo sapiens | 2 | ALA3108749 | cell-based format | Scientific Literature | |
10. | ALA3111004 | Binding | Inhibition of 17-beta HSD7 (unknown origin) transfected in HEK293 cells using [14C]E1 as substrate at 10 uM | Homo sapiens | 3 | ALA3108749 | cell-based format | Scientific Literature | |
11. | ALA3111005 | Binding | Inhibition of 17-beta HSD2 (unknown origin) transfected in HEK293 cells using [14C]E2 as substrate at 10 uM | Homo sapiens | 2 | ALA3108749 | cell-based format | Scientific Literature | |
12. | ALA3111006 | Binding | Inhibition of 17-beta HSD1 in human T47D cells | Homo sapiens | 1 | ALA3108749 | cell-based format | Scientific Literature | |
13. | ALA3111007 | Binding | Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 after 24 hrs by thin layer chromatography | Homo sapiens | 5 | ALA3108749 | cell-based format | Scientific Literature | |
14. | ALA3111010 | Functional | Cytotoxicity against human estrogen-starved estrogen-sensitive MCF7 cells assessed as cell growth at 1 uM after 7 days by MTS assay relative to control | Homo sapiens | 20 | ALA3108749 | cell-based format | Scientific Literature | |
15. | ALA3111011 | Functional | Cytotoxicity against human estrogen-starved estrogen-sensitive MCF7 cells assessed as cell growth at 0.1 uM after 7 days by MTS assay relative to control | Homo sapiens | 20 | ALA3108749 | cell-based format | Scientific Literature | |
16. | ALA3111012 | Binding | Inhibition of 17-beta HSD1 in human T47D cells assessed as transformation of [14C]E1 to [14C]E2 at 0.1 uM after 24 hrs by thin layer chromatography | Homo sapiens | 26 | ALA3108749 | cell-based format | Scientific Literature |