# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2214870 | A | Apparent permeability of the compound across apical to basolateral side in wild type MDCK cells at 10 uM | Canis lupus familiaris | 2 | ALA2203174 | cell-based format | Scientific Literature | |
2. | ALA2214875 | A | Efflux ratio of permeability in MDCK cells expressing MDR1 at 10 uM | Canis lupus familiaris | 2 | ALA2203174 | cell-based format | Scientific Literature | |
3. | ALA2214876 | A | Intrinsic clearance in human liver microsomes at 1 uM by LC-MS/MS analysis | Homo sapiens | 2 | ALA2203174 | microsome format | Scientific Literature | |
4. | ALA2214877 | A | Intrinsic clearance in mouse liver microsomes at 1 uM by LC-MS/MS analysis | Mus musculus | 2 | ALA2203174 | microsome format | Scientific Literature | |
5. | ALA2214878 | A | Half life in mouse plasma at 1 uM by LC-MS/MS analysis | Mus musculus | 2 | ALA2203174 | cell-free format | Scientific Literature | |
6. | ALA2214879 | A | Half life in human plasma at 1 uM by LC-MS/MS analysis | Homo sapiens | 2 | ALA2203174 | cell-free format | Scientific Literature | |
7. | ALA2214881 | P | Kinetic solubility of the compound in PBS at pH 7.4 by LC-UV analysis | 2 | ALA2203174 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA2214882 | B | Inhibition of coagulation factor 13a | 4 | ALA2203174 | single protein format | Scientific Literature | ||
9. | ALA2214883 | B | Inhibition of transglutaminase 6 | 3 | ALA2203174 | single protein format | Scientific Literature | ||
10. | ALA2214884 | B | Inhibition of transglutaminase 3 | 4 | ALA2203174 | single protein format | Scientific Literature | ||
11. | ALA2214885 | B | Inhibition of transglutaminase 1 | 4 | ALA2203174 | single protein format | Scientific Literature | ||
12. | ALA2214887 | B | Irreversible inhibition of transglutaminase 2 | 44 | ALA2203174 | single protein format | Scientific Literature | ||
13. | ALA4024886 | A | Metabolic stability in Wistar rat blood plasma after 15 mins by HPLC analysis | Rattus norvegicus | 1 | ALA4024703 | cell-free format | Scientific Literature | |
14. | ALA4024887 | A | Metabolic stability in Wistar rat blood plasma after 45 mins by HPLC analysis | Rattus norvegicus | 1 | ALA4024703 | cell-free format | Scientific Literature | |
15. | ALA4223773 | B | Inhibition of human TGase 2 using R-I-Cad/DMC as substrate preincubated for 5 mins followed by substrate addition measured at 30 secs interval over 900 secs by fluorescence anisotropy assay | Homo sapiens | 12 | ALA4219231 | single protein format | Scientific Literature | |
16. | ALA4223774 | B | Inhibition of guinea pig TGase 2 using F-Cad/DMC as substrate preincubated for 30 mins followed by substrate addition measured at 30 secs interval over 900 secs by fluorescence anisotropy assay | Cavia porcellus | 15 | ALA4219231 | assay format | Scientific Literature | |
17. | ALA4223775 | B | Irreversible inhibition of mouse TGase 2 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Mus musculus | 3 | ALA4219231 | single protein format | Scientific Literature | |
18. | ALA4223776 | B | Irreversible inhibition of human TGase 1 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | ALA4219231 | single protein format | Scientific Literature | |
19. | ALA4223777 | B | Irreversible inhibition of human TGase 3 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | ALA4219231 | single protein format | Scientific Literature | |
20. | ALA4223778 | B | Irreversible inhibition of human TGase 6 assessed as ratio of Kinact/Ki using Z-Glu(HMC)-Gly-OH as substrate measured at 20 secs interval over 900 secs by fluorimetric assay | Homo sapiens | 3 | ALA4219231 | single protein format | Scientific Literature |