# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2214124 | F | Ratio of compound IC50 to Dp44mT IC50 for human A549 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA2214125 | F | Antiproliferative activity at human MRC5 cells after 72 hrs by MTT assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
3. | ALA2214126 | F | Antiproliferative activity at human A549 cells after 72 hrs by MTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
4. | ALA2214127 | F | Antiproliferative activity at human DMS53 cells after 72 hrs by MTT assay | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
5. | ALA2214130 | F | Ratio of Dp4mT IC50 to compound IC50 for human SK-N-MC cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA2214131 | F | Antiproliferative activity at human SK-N-MC cells after 72 hrs by MTT assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
7. | ALA3858193 | F | Antiproliferative activity against human KB3-1 cells after 24 hrs by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
8. | ALA3858194 | F | Antiproliferative activity against human KB3-1 cells after 24 hrs in presence of P-gp inhibitor elacridar by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
9. | ALA3858196 | F | Antiproliferative activity against human KBV1 cells over expressing P-gp after 24 hrs in presence of P-gp inhibitor elacridar by MTT assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
10. | ALA3858197 | F | Selectivity ratio of IC50 for human KB31 cells to IC50 for human KBV1 cells over expressing P-gp | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
11. | ALA3858198 | B | Substrate activity at P-gp (unknown origin) in P-gp enriched membranes assessed as increase in ATPase activity at 50 uM in presence of Mg2-ATP after 40 mins by luciferase reporter gen assay relative to control | Homo sapiens | 6 | cell membrane format | Scientific Literature | ||
12. | ALA3858201 | F | Induction of lysosomal membrane permeabilization in human KB3-1 cells at 10 uM after 30 mins by acridine orange staining based fluorescence microscopic analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
13. | ALA3858202 | F | Induction of lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by acridine orange staining based fluorescence microscopic analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
14. | ALA3858203 | F | Induction of ROS accumulation in human KBV1 cells over expressing P-gp at 10 uM after 30 mins by DCF-DA staining based flow cytometry | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
15. | ALA3858209 | B | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as cathepsin D release from lysosome to cytosol at 25 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
16. | ALA3858210 | B | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as increase in LAMP2 fluorescence at 25 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
17. | ALA3858211 | B | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as cathepsin D release from lysosome to cytosol at 25 uM after 24 hrs in presence of P-gp inhibitor elacridar by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
18. | ALA3858212 | B | Induction of P-gp-mediated lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as increase in LAMP2 fluorescence at 25 uM after 24 hrs in presence of P-gp inhibitor elacridar by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
19. | ALA3858214 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
20. | ALA3858216 | F | Induction of copper-dependent lysosomal membrane permeabilization in human KBV1 cells over expressing P-gp assessed as decrease in cathepsin D and LAMP2 lysosomal colocalization at 25 uM after 24 hrs in presence of Cu chelator tetrathiomolybdate by TexasRed staining based immunofluorescence microscopic analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |