| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2212449 | B | Irreversible inhibition of PAD1 for 1 hr by dialysis | 2 | single protein format | Scientific Literature | |||
| 2. | ALA2212450 | B | Irreversible inhibition of PAD1 at 15 to 500 uM after 30 mins by competitive ABPP assay | 2 | single protein format | Scientific Literature | |||
| 3. | ALA2212451 | A | Drug level in C57Bl/6 mouse serum at 10 mg/kg, ip after 4 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 4. | ALA2212452 | A | Drug level in C57Bl/6 mouse serum at 2.5 mg/kg, iv after 4 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA2212453 | A | Drug level in C57Bl/6 mouse serum at 2.5 mg/kg, iv after 2 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA2212455 | A | Half life in mouse liver microsomes | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 7. | ALA2212458 | F | Induction of apoptosis in human MDA-MB-231 cells assessed as increase in caspase-3 activity | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA2212460 | F | Antiproliferative activity against human MDA-MB-231 cells assessed as Ki-67 level at 100 to 400 uM | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA2212462 | F | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell number at 400 uM after 96 hrs by trypan blue assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA2212463 | F | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell viability at 200 to 400 uM after 96 hrs by trypan blue assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA2212464 | T | Toxicity in po dosed C57BL/6J mouse | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA2212465 | T | Toxicity in C57BL/6J mouse assessed as change in body weight at 5 to 150 mg/kg, po after 1 to 96 hrs | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA2212470 | B | Selectivity ratio of Kinact to Ki for PAD1 to Kinact to Ki for PAD4 | 6 | assay format | Scientific Literature | |||
| 14. | ALA2212471 | B | Selectivity ratio of Kinact to Ki for PAD1 to Kinact to Ki for PAD3 | 6 | assay format | Scientific Literature | |||
| 15. | ALA2212939 | B | Ratio of Kinact to Ki for PAD4 | 11 | single protein format | Scientific Literature | |||
| 16. | ALA2212940 | B | Selectivity ratio of Kinact to Ki for PAD1 to Kinact to Ki for PAD2 | 6 | assay format | Scientific Literature | |||
| 17. | ALA2212941 | B | Ratio of Kinact to Ki for PAD3 | 11 | single protein format | Scientific Literature | |||
| 18. | ALA2212942 | B | Ratio of Kinact to Ki for PAD1 | 11 | single protein format | Scientific Literature | |||
| 19. | ALA2212943 | B | Ratio of Kinact to Ki for PAD2 | 11 | single protein format | Scientific Literature |
The page will load shortly, Thanks for your patience!