# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2215341 | Functional | Target occupancy at SERT in Harlan rat at 5 mg/kg, sc administered QD for 3 days relative to vehicle-treated control | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
2. | ALA2215342 | Functional | Target occupancy at SERT in Harlan rat at 10 mg/kg, sc administered QD for 3 days relative to vehicle-treated control | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
3. | ALA2215343 | Functional | Antidepression activity in Harlan rat assessed as increase in extracellular 5HT level in medial prefrontal cortex region at 5 to 10 mg/kg, sc administered QD for 3 days by microdialysis method | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
4. | ALA2215344 | Functional | Antidepression activity in Harlan rat assessed as increase in extracellular 5HT level in ventral hippocampus region at 5 to 10 mg/kg, sc measured from 40 to 180 mins by microdialysis method | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
5. | ALA2215345 | Functional | Antidepression activity in Harlan rat assessed as increase in extracellular 5HT level in ventral hippocampus region at 2.5 mg/kg, sc measured from 60 to 120 mins by microdialysis method | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
6. | ALA2215346 | Functional | Antidepression activity in Harlan rat assessed as increase in extracellular 5HT level in ventral hippocampus region at 2.5 to 10 mg/kg, sc by microdialysis method | Rattus norvegicus | 1 | ALA2203036 | organism-based format | Scientific Literature | |
7. | ALA2215348 | Functional | Antagonist activity at human 5HT7 receptor expressed in HEK-CNG cells assessed as effect on cAMP production by fluorescence based assay | Homo sapiens | 1 | ALA2203036 | cell-based format | Scientific Literature | |
8. | ALA2215349 | Functional | Partial agonist activity at human 5HT1B receptor expressed in CHO cells assessed as [35S]GTPgammaS binding relative to 5HT | Homo sapiens | 1 | ALA2203036 | cell-based format | Scientific Literature | |
9. | ALA2215350 | Binding | Inhibition of human NET at 1 uM | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
10. | ALA2215351 | Binding | Binding affinity to human 5HT7 receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
11. | ALA2215352 | Binding | Binding affinity to human 5HT6 receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
12. | ALA2215353 | Binding | Binding affinity to human 5HT5A receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
13. | ALA2215354 | Binding | Inhibition of human 5HT3A receptor at 1 uM | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
14. | ALA2215355 | Binding | Binding affinity to human 5HT2C receptor | Homo sapiens | 2 | ALA2203036 | single protein format | Scientific Literature | |
15. | ALA2215356 | Binding | Binding affinity to human 5HT2A receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
16. | ALA2215357 | Binding | Inhibition of human 5HT1B receptor at 1 uM | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
17. | ALA2215358 | Binding | Inhibition of human 5HT1A receptor at 1 uM | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
18. | ALA2215359 | Binding | Binding affinity to human beta 2 adrenergic receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
19. | ALA2215360 | Binding | Binding affinity to human beta 1 adrenergic receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature | |
20. | ALA2215361 | Binding | Binding affinity to human histamine H2 receptor | Homo sapiens | 1 | ALA2203036 | single protein format | Scientific Literature |