# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2212223 | B | Covalent binding affinity to human recombinant TRX-2 assessed as change in protein configuration at 0.05 mM by MALDITOF mass spectrometry | Homo sapiens | 6 | ALA2203071 | single protein format | Scientific Literature | |
2. | ALA2212224 | B | Covalent binding affinity to human recombinant TRX-1 assessed as change in protein configuration at 0.1 mM by MALDITOF mass spectrometry | Homo sapiens | 6 | ALA2203071 | single protein format | Scientific Literature | |
3. | ALA3541715 | P | Drug level in PBS buffer treated with gambogic acid at 50 uM preincubated for 10 mins followed by NADPH addition measured after 1 hr by LC-DAD-MS/MS analysis in absence of liver microsomes | 1 | ALA3526153 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA3532167 | A | Retention time of the compound in Sprague-Dawley rat bile treated with gambogic acid at 4 mg/kg, iv measured over 24 hrs by LC-DAD-MS/MS analysis | Rattus norvegicus | 13 | ALA3526153 | organism-based format | Scientific Literature | |
5. | ALA3535477 | A | Drug level in rat liver microsomes assessed as CYP450-mediated compound formation treated with gambogic acid at 50 uM preincubated for 10 mins followed by NADPH addition measured after 1 hr by LC-DAD-MS/MS analysis | Rattus norvegicus | 2 | ALA3526153 | assay format | Scientific Literature | |
6. | ALA3535478 | A | Drug level in Sprague-Dawley rat feces treated with gambogic acid at 4 mg/kg, iv measured over 24 hrs by LC-DAD-MS/MS analysis | Rattus norvegicus | 4 | ALA3526153 | organism-based format | Scientific Literature | |
7. | ALA3535480 | A | Drug level in Sprague-Dawley rat plasma treated with gambogic acid at 4 mg/kg, iv measured over 4 hrs by LC-DAD-MS/MS analysis | Rattus norvegicus | 1 | ALA3526153 | organism-based format | Scientific Literature |