Agonist activity at TrkA receptor in C57BL/J6 mouse brain assessed as TrkA phosphorylation at tyrosine 794 in cortex at 5 mg/kg, po administered qd for 21 days by immunoblotting analysis
Agonist activity at TrkB receptor in C57BL/J6 mouse brain assessed as TrkB phosphorylation at tyrosine 816 in cortex at 5 mg/kg, po administered qd for 21 days by immunoblotting analysis
Antidepressant activity in C57BL/J6 mouse assessed as reduction of immobility at 5 mg/kg, po administered qd for 21 days recorded in last 4 mins by forced swim test
Agonist activity at TrkB receptor in C57BL/J6 mouse brain assessed as Akt phosphorylation at serine 473 in hippocampus at 1 mg/kg, po after 4 hrs by ELISA
Agonist activity at TrkB receptor in C57BL/J6 mouse brain assessed as TrkB phosphorylation at tyrosine 816 in hippocampus at 1 mg/kg, po after 4 hrs by immunoblotting analysis
Agonist activity at TrkB receptor in E17 rat embryo primary neurons assessed as Akt phosphorylation at serine 473 at 500 nM after 15 mins by immunoblotting analysis
Agonist activity at TrkB receptor in E17 rat embryo primary neurons assessed as TrkB phosphorylation at tyrosine 817 at 500 nM after 15 mins by immunoblotting analysis