# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA2214982 | ADME | Inhibition of cytochrome P450 3A4 | 3 | ALA2202966 | single protein format | Scientific Literature | ||
2. | ALA2214983 | ADME | In vitro clearance in human | Homo sapiens | 1 | ALA2202966 | organism-based format | Scientific Literature | |
3. | ALA2214984 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of neutrophil recruitment after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
4. | ALA2214985 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment administered two doses prior to thioglycollate challenge followed by third dose at 3 hr measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
5. | ALA2214986 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis wild type mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 20 mg/kg administered 1 hr prior to thioglycollate challenge followed by second dose at 3 hr measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
6. | ALA2214987 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 20 mg/kg administered 1 hr prior to thioglycollate challenge followed by second dose at 3 hr measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
7. | ALA2212582 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 20 mg/kg administered 3 hr after thioglycollate challenge measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
8. | ALA2212583 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 20 mg/kg administered 1 hr prior to thioglycollate challenge measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
9. | ALA2212584 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 10 mg/kg administered two doses prior to thioglycollate challenge followed by third dose at 3 hr measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
10. | ALA2212585 | Functional | Antiinflammatory activity against thioglycollate-induced peritonitis knock-in mouse model expressing human CCR2 assessed as reduction of monocyte recruitment at 20 mg/kg administered two doses prior to thioglycollate challenge followed by third dose at 3 hr measured after 6 hrs by FACS analysis | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
11. | ALA2212586 | ADME | Half life in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
12. | ALA2212587 | ADME | Plasma clearance in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
13. | ALA2212588 | ADME | Oral bioavailability in mouse at 20 mg/kg | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
14. | ALA2212589 | ADME | Oral bioavailability in mouse at 2 mg/kg | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
15. | ALA2212590 | ADME | AUC (0 to infinity) in mouse at 20 mg/kg, po | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
16. | ALA2212591 | ADME | AUC (0 to infinity) in mouse at 2 mg/kg, po | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
17. | ALA2212592 | ADME | AUC (0 to infinity) in mouse at 1 mg/kg, iv | Mus musculus | 1 | ALA2202966 | organism-based format | Scientific Literature | |
18. | ALA2212593 | Functional | Antagonist activity at CCR2 in human whole blood assessed as inhibition of CCL2-stimulated monocyte shape change | Homo sapiens | 1 | ALA2202966 | tissue-based format | Scientific Literature | |
19. | ALA2212594 | ADME | Plasma protein binding in mouse | Mus musculus | 1 | ALA2202966 | cell-free format | Scientific Literature | |
20. | ALA2212595 | ADME | Plasma protein binding in human | Homo sapiens | 1 | ALA2202966 | cell-free format | Scientific Literature |