| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA2216961 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as TNFalpha production at 30 uM after 3 days by FACS flow cytometric analysis (Rvb = 91.3 +/- 34.5 pg/mL) | Mus musculus | 6 | assay format | Scientific Literature | ||
| 2. | ALA2216962 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as IL-1beta production at 30 uM after 3 days by FACS flow cytometric analysis (Rvb = 26.2 +/- 3.7 pg/mL) | Mus musculus | 6 | assay format | Scientific Literature | ||
| 3. | ALA2216963 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as IL-12p40 production at 30 uM after 3 days by FACS flow cytometric analysis (Rvb = 260.6 +/- 11.9 pg/mL) | Mus musculus | 6 | assay format | Scientific Literature | ||
| 4. | ALA2216964 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as IL-10 production at 30 uM after 3 days by FACS flow cytometric analysis (Rvb = 16.2 +/- 4.7 pg/mL) | Mus musculus | 6 | assay format | Scientific Literature | ||
| 5. | ALA2216965 | F | Agonist activity at human TLR7 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA2216966 | F | Agonist activity at human TLR8 transfected in HEK cells assessed as NFkappaB induction after 24 hrs by specific secreted alkaline phosphatase gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 7. | ALA2216969 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as TNFalpha production at 30 uM after 3 days by FACS flow cytometric analysis relative to imiquimod | Mus musculus | 1 | assay format | Scientific Literature | ||
| 8. | ALA2216970 | F | Immunomodulatory activity in C57BL/6 mouse BMDC assessed as IL-12p40 production at 30 uM after 3 days by FACS flow cytometric analysis relative to imiquimod | Mus musculus | 1 | assay format | Scientific Literature | ||
| 9. | ALA3116704 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-10 production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | protein format | Scientific Literature | ||
| 10. | ALA3116705 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-12p40 production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | protein format | Scientific Literature | ||
| 11. | ALA3116706 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of IL-1beta production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | protein format | Scientific Literature | ||
| 12. | ALA3116707 | B | Agonist activity at TLR7/TLR8 in C57BL/6 mouse BMDC assessed as induction of TNF-alpha production at 30 uM after 3 days by flow cytometric analysis | Mus musculus | 15 | protein format | Scientific Literature | ||
| 13. | ALA3116708 | B | Agonist activity at human TLR-8 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 14. | ALA3116709 | B | Agonist activity at human TLR-7 expressed in HEK293 cells after 24 hrs by SEAP reporter gene assay | Homo sapiens | 15 | cell-based format | Scientific Literature |
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